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Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control
The hypothalamic neurohormone oxytocin decreases food intake via largely unexplored mechanisms. We investigated the central nervous mediation of oxytocin’s hypophagic effect in comparison to its impact on the processing of generalized rewards. Fifteen fasted normal-weight, young men received intrana...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807408/ https://www.ncbi.nlm.nih.gov/pubmed/29426874 http://dx.doi.org/10.1038/s41598-018-20963-4 |
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author | Spetter, Maartje S. Feld, Gordon B. Thienel, Matthias Preissl, Hubert Hege, Maike A. Hallschmid, Manfred |
author_facet | Spetter, Maartje S. Feld, Gordon B. Thienel, Matthias Preissl, Hubert Hege, Maike A. Hallschmid, Manfred |
author_sort | Spetter, Maartje S. |
collection | PubMed |
description | The hypothalamic neurohormone oxytocin decreases food intake via largely unexplored mechanisms. We investigated the central nervous mediation of oxytocin’s hypophagic effect in comparison to its impact on the processing of generalized rewards. Fifteen fasted normal-weight, young men received intranasal oxytocin (24 IU) or placebo before functional magnetic resonance imaging (fMRI) measurements of brain activity during exposure to food stimuli and a monetary incentive delay task (MID). Subsequently, ad-libitum breakfast intake was assessed. Oxytocin compared to placebo increased activity in the ventromedial prefrontal cortex, supplementary motor area, anterior cingulate, and ventrolateral prefrontal cortices in response to high- vs. low-calorie food images in the fasted state, and reduced calorie intake by 12%. During anticipation of monetary rewards, oxytocin compared to placebo augmented striatal, orbitofrontal and insular activity without altering MID performance. We conclude that during the anticipation of generalized rewards, oxytocin stimulates dopaminergic reward-processing circuits. In contrast, oxytocin restrains food intake by enhancing the activity of brain regions that exert cognitive control, while concomitantly increasing the activity of structures that process food reward value. This pattern points towards a specific role of oxytocin in the regulation of eating behaviour in humans that might be of relevance for potential clinical applications. |
format | Online Article Text |
id | pubmed-5807408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58074082018-02-14 Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control Spetter, Maartje S. Feld, Gordon B. Thienel, Matthias Preissl, Hubert Hege, Maike A. Hallschmid, Manfred Sci Rep Article The hypothalamic neurohormone oxytocin decreases food intake via largely unexplored mechanisms. We investigated the central nervous mediation of oxytocin’s hypophagic effect in comparison to its impact on the processing of generalized rewards. Fifteen fasted normal-weight, young men received intranasal oxytocin (24 IU) or placebo before functional magnetic resonance imaging (fMRI) measurements of brain activity during exposure to food stimuli and a monetary incentive delay task (MID). Subsequently, ad-libitum breakfast intake was assessed. Oxytocin compared to placebo increased activity in the ventromedial prefrontal cortex, supplementary motor area, anterior cingulate, and ventrolateral prefrontal cortices in response to high- vs. low-calorie food images in the fasted state, and reduced calorie intake by 12%. During anticipation of monetary rewards, oxytocin compared to placebo augmented striatal, orbitofrontal and insular activity without altering MID performance. We conclude that during the anticipation of generalized rewards, oxytocin stimulates dopaminergic reward-processing circuits. In contrast, oxytocin restrains food intake by enhancing the activity of brain regions that exert cognitive control, while concomitantly increasing the activity of structures that process food reward value. This pattern points towards a specific role of oxytocin in the regulation of eating behaviour in humans that might be of relevance for potential clinical applications. Nature Publishing Group UK 2018-02-09 /pmc/articles/PMC5807408/ /pubmed/29426874 http://dx.doi.org/10.1038/s41598-018-20963-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Spetter, Maartje S. Feld, Gordon B. Thienel, Matthias Preissl, Hubert Hege, Maike A. Hallschmid, Manfred Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control |
title | Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control |
title_full | Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control |
title_fullStr | Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control |
title_full_unstemmed | Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control |
title_short | Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control |
title_sort | oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807408/ https://www.ncbi.nlm.nih.gov/pubmed/29426874 http://dx.doi.org/10.1038/s41598-018-20963-4 |
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