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A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors
A significant problem in high-throughput drug screening is the disproportionate number of false hits associated with drug candidates that form colloidal aggregates. Such molecules, referred to as promiscuous inhibitors, nonspecifically inhibit multiple enzymes and are thus not useful as potential dr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807445/ https://www.ncbi.nlm.nih.gov/pubmed/29426913 http://dx.doi.org/10.1038/s41467-018-02956-z |