A biopotential optrode array: operation principles and simulations

We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological cells and t...

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Autores principales: Al Abed, Amr, Srinivas, Hrishikesh, Firth, Josiah, Ladouceur, François, Lovell, Nigel H., Silvestri, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807498/
https://www.ncbi.nlm.nih.gov/pubmed/29426924
http://dx.doi.org/10.1038/s41598-018-20182-x
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author Al Abed, Amr
Srinivas, Hrishikesh
Firth, Josiah
Ladouceur, François
Lovell, Nigel H.
Silvestri, Leonardo
author_facet Al Abed, Amr
Srinivas, Hrishikesh
Firth, Josiah
Ladouceur, François
Lovell, Nigel H.
Silvestri, Leonardo
author_sort Al Abed, Amr
collection PubMed
description We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electro-optical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis. Simulations indicate that the device has appropriate temporal response to faithfully transduce neuronal spikes, and spatial resolution to capture impulse propagation along a single neuron. These simulations contribute to the development of multi-channel optrode arrays for spatio-temporal mapping of electric events in excitable biological tissue.
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spelling pubmed-58074982018-02-14 A biopotential optrode array: operation principles and simulations Al Abed, Amr Srinivas, Hrishikesh Firth, Josiah Ladouceur, François Lovell, Nigel H. Silvestri, Leonardo Sci Rep Article We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electro-optical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis. Simulations indicate that the device has appropriate temporal response to faithfully transduce neuronal spikes, and spatial resolution to capture impulse propagation along a single neuron. These simulations contribute to the development of multi-channel optrode arrays for spatio-temporal mapping of electric events in excitable biological tissue. Nature Publishing Group UK 2018-02-09 /pmc/articles/PMC5807498/ /pubmed/29426924 http://dx.doi.org/10.1038/s41598-018-20182-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Al Abed, Amr
Srinivas, Hrishikesh
Firth, Josiah
Ladouceur, François
Lovell, Nigel H.
Silvestri, Leonardo
A biopotential optrode array: operation principles and simulations
title A biopotential optrode array: operation principles and simulations
title_full A biopotential optrode array: operation principles and simulations
title_fullStr A biopotential optrode array: operation principles and simulations
title_full_unstemmed A biopotential optrode array: operation principles and simulations
title_short A biopotential optrode array: operation principles and simulations
title_sort biopotential optrode array: operation principles and simulations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807498/
https://www.ncbi.nlm.nih.gov/pubmed/29426924
http://dx.doi.org/10.1038/s41598-018-20182-x
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