Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues

Dipeptidyl peptidase IV (DPP IV, DPP4, or DAP IV) preferentially cleaves substrate peptides with Pro or Ala at the P1 position. The substrate recognition mechanism has been fully elucidated for mammalian DPP IV by crystal structure analyses but not for bacterial orthologues. Here, we report the crys...

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Detalles Bibliográficos
Autores principales: Roppongi, Saori, Suzuki, Yoshiyuki, Tateoka, Chika, Fujimoto, Mayu, Morisawa, Saori, Iizuka, Ippei, Nakamura, Akihiro, Honma, Nobuyuki, Shida, Yosuke, Ogasawara, Wataru, Tanaka, Nobutada, Sakamoto, Yasumitsu, Nonaka, Takamasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807507/
https://www.ncbi.nlm.nih.gov/pubmed/29426867
http://dx.doi.org/10.1038/s41598-018-21056-y

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