Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

Mouse models indicate that metastatic dissemination occurs extremely early; however, the timing in human cancers is unknown. We therefore determined the time point of metastatic seeding relative to tumour thickness and genomic alterations in melanoma. Here, we find that lymphatic dissemination occur...

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Detalles Bibliográficos
Autores principales: Werner-Klein, Melanie, Scheitler, Sebastian, Hoffmann, Martin, Hodak, Isabelle, Dietz, Klaus, Lehnert, Petra, Naimer, Veronika, Polzer, Bernhard, Treitschke, Steffi, Werno, Christian, Markiewicz, Aleksandra, Weidele, Kathrin, Czyz, Zbigniew, Hohenleutner, Ulrich, Hafner, Christian, Haferkamp, Sebastian, Berneburg, Mark, Rümmele, Petra, Ulmer, Anja, Klein, Christoph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807512/
https://www.ncbi.nlm.nih.gov/pubmed/29426936
http://dx.doi.org/10.1038/s41467-017-02674-y

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