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Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma

Our current view of DNA methylation processes is strongly moving: First, even if it was generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and DNMT1 is associated with inheritance DNA methylation, these distinctions are now not so clear. Secondly, since one decade, man...

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Autores principales: Hervouet, Eric, Peixoto, Paul, Delage-Mourroux, Régis, Boyer-Guittaut, Michaël, Cartron, Pierre-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807744/
https://www.ncbi.nlm.nih.gov/pubmed/29449903
http://dx.doi.org/10.1186/s13148-018-0450-y
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author Hervouet, Eric
Peixoto, Paul
Delage-Mourroux, Régis
Boyer-Guittaut, Michaël
Cartron, Pierre-François
author_facet Hervouet, Eric
Peixoto, Paul
Delage-Mourroux, Régis
Boyer-Guittaut, Michaël
Cartron, Pierre-François
author_sort Hervouet, Eric
collection PubMed
description Our current view of DNA methylation processes is strongly moving: First, even if it was generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and DNMT1 is associated with inheritance DNA methylation, these distinctions are now not so clear. Secondly, since one decade, many partners of DNMTs have been involved in both the regulation of DNA methylation activity and DNMT recruitment on DNA. The high diversity of interactions and the combination of these interactions let us to subclass the different DNMT-including complexes. For example, the DNMT3L/DNMT3A complex is mainly related to de novo DNA methylation in embryonic states, whereas the DNMT1/PCNA/UHRF1 complex is required for maintaining global DNA methylation following DNA replication. On the opposite to these unspecific DNA methylation machineries (no preferential DNA sequence), some recently identified DNMT-including complexes are recruited on specific DNA sequences. The coexistence of both types of DNA methylation (un/specific) suggests a close cooperation and an orchestration between these systems to maintain genome and epigenome integrities. Deregulation of these systems can lead to pathologic disorders.
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spelling pubmed-58077442018-02-15 Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma Hervouet, Eric Peixoto, Paul Delage-Mourroux, Régis Boyer-Guittaut, Michaël Cartron, Pierre-François Clin Epigenetics Review Our current view of DNA methylation processes is strongly moving: First, even if it was generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and DNMT1 is associated with inheritance DNA methylation, these distinctions are now not so clear. Secondly, since one decade, many partners of DNMTs have been involved in both the regulation of DNA methylation activity and DNMT recruitment on DNA. The high diversity of interactions and the combination of these interactions let us to subclass the different DNMT-including complexes. For example, the DNMT3L/DNMT3A complex is mainly related to de novo DNA methylation in embryonic states, whereas the DNMT1/PCNA/UHRF1 complex is required for maintaining global DNA methylation following DNA replication. On the opposite to these unspecific DNA methylation machineries (no preferential DNA sequence), some recently identified DNMT-including complexes are recruited on specific DNA sequences. The coexistence of both types of DNA methylation (un/specific) suggests a close cooperation and an orchestration between these systems to maintain genome and epigenome integrities. Deregulation of these systems can lead to pathologic disorders. BioMed Central 2018-02-09 /pmc/articles/PMC5807744/ /pubmed/29449903 http://dx.doi.org/10.1186/s13148-018-0450-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Hervouet, Eric
Peixoto, Paul
Delage-Mourroux, Régis
Boyer-Guittaut, Michaël
Cartron, Pierre-François
Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
title Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
title_full Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
title_fullStr Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
title_full_unstemmed Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
title_short Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
title_sort specific or not specific recruitment of dnmts for dna methylation, an epigenetic dilemma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807744/
https://www.ncbi.nlm.nih.gov/pubmed/29449903
http://dx.doi.org/10.1186/s13148-018-0450-y
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