Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

BACKGROUND: The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN. Furthermore, in endometrial cancer (EC), PI3K and RAS/RAF/MEK/MAPK (RAS/MAPK herein) pathway mutations frequently co-exist. We examined the...

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Detalles Bibliográficos
Autores principales: Aslan, Ozlem, Cremona, Mattia, Morgan, Clare, Cheung, Lydia W., Mills, Gordon B., Hennessy, Bryan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807759/
https://www.ncbi.nlm.nih.gov/pubmed/29426295
http://dx.doi.org/10.1186/s12885-018-4035-0

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