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Avian malaria and bird humoral immune response
BACKGROUND: Plasmodium parasites are known to impose fitness costs on their vertebrate hosts. Some of these costs are due to the activation of the immune response, which may divert resources away from self-maintenance. Plasmodium parasites may also immuno-deplete their hosts. Thus, infected individu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807826/ https://www.ncbi.nlm.nih.gov/pubmed/29426311 http://dx.doi.org/10.1186/s12936-018-2219-3 |
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author | Delhaye, Jessica Jenkins, Tania Glaizot, Olivier Christe, Philippe |
author_facet | Delhaye, Jessica Jenkins, Tania Glaizot, Olivier Christe, Philippe |
author_sort | Delhaye, Jessica |
collection | PubMed |
description | BACKGROUND: Plasmodium parasites are known to impose fitness costs on their vertebrate hosts. Some of these costs are due to the activation of the immune response, which may divert resources away from self-maintenance. Plasmodium parasites may also immuno-deplete their hosts. Thus, infected individuals may be less able to mount an immune response to a new pathogen than uninfected ones. However, this has been poorly investigated. METHODS: The effect of Plasmodium infection on bird humoral immune response when encountering a novel antigen was tested. A laboratory experiment was conducted on canaries (Serinus canaria) experimentally infected with Plasmodium relictum (lineage SGS1) under controlled conditions. Birds were immune challenged with an intra-pectoral injection of a novel non-pathogenic antigen (keyhole limpet haemocyanin, KLH). One week later they were challenged again. The immune responses to the primary and to the secondary contacts were quantified as anti-KLH antibody production via enzyme-linked immunosorbent assay (ELISA). RESULTS: There was no significant difference in antibody production between uninfected and Plasmodium infected birds at both primary and secondary contact. However, Plasmodium parasite intensity in the blood increased after the primary contact with the antigen. CONCLUSIONS: There was no effect of Plasmodium infection on the magnitude of the humoral immune response. However, there was a cost of mounting an immune response in infected individuals as parasitaemia increased after the immune challenge, suggesting a trade-off between current control of chronic Plasmodium infection and investment against a new immune challenge. |
format | Online Article Text |
id | pubmed-5807826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58078262018-02-15 Avian malaria and bird humoral immune response Delhaye, Jessica Jenkins, Tania Glaizot, Olivier Christe, Philippe Malar J Research BACKGROUND: Plasmodium parasites are known to impose fitness costs on their vertebrate hosts. Some of these costs are due to the activation of the immune response, which may divert resources away from self-maintenance. Plasmodium parasites may also immuno-deplete their hosts. Thus, infected individuals may be less able to mount an immune response to a new pathogen than uninfected ones. However, this has been poorly investigated. METHODS: The effect of Plasmodium infection on bird humoral immune response when encountering a novel antigen was tested. A laboratory experiment was conducted on canaries (Serinus canaria) experimentally infected with Plasmodium relictum (lineage SGS1) under controlled conditions. Birds were immune challenged with an intra-pectoral injection of a novel non-pathogenic antigen (keyhole limpet haemocyanin, KLH). One week later they were challenged again. The immune responses to the primary and to the secondary contacts were quantified as anti-KLH antibody production via enzyme-linked immunosorbent assay (ELISA). RESULTS: There was no significant difference in antibody production between uninfected and Plasmodium infected birds at both primary and secondary contact. However, Plasmodium parasite intensity in the blood increased after the primary contact with the antigen. CONCLUSIONS: There was no effect of Plasmodium infection on the magnitude of the humoral immune response. However, there was a cost of mounting an immune response in infected individuals as parasitaemia increased after the immune challenge, suggesting a trade-off between current control of chronic Plasmodium infection and investment against a new immune challenge. BioMed Central 2018-02-09 /pmc/articles/PMC5807826/ /pubmed/29426311 http://dx.doi.org/10.1186/s12936-018-2219-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Delhaye, Jessica Jenkins, Tania Glaizot, Olivier Christe, Philippe Avian malaria and bird humoral immune response |
title | Avian malaria and bird humoral immune response |
title_full | Avian malaria and bird humoral immune response |
title_fullStr | Avian malaria and bird humoral immune response |
title_full_unstemmed | Avian malaria and bird humoral immune response |
title_short | Avian malaria and bird humoral immune response |
title_sort | avian malaria and bird humoral immune response |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807826/ https://www.ncbi.nlm.nih.gov/pubmed/29426311 http://dx.doi.org/10.1186/s12936-018-2219-3 |
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