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Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population

Racial and ethnic disparities in malignancies attract extensive attention. To investigate whether there are racial and ethnic disparities in genetic alteration between Caucasian and Eastern Asian population, data from several prospective AML trials were retrospectively analyzed in this study. We fou...

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Autores principales: Wei, Hui, Wang, Ying, Zhou, Chunlin, Lin, Dong, Liu, Bingcheng, Liu, Kaiqi, Qiu, Shaowei, Gong, Benfa, Li, Yan, Zhang, Guangji, Wei, Shuning, Gong, Xiaoyuan, Liu, Yuntao, Zhao, Xingli, Gu, Runxia, Mi, Yingchang, Wang, Jianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807853/
https://www.ncbi.nlm.nih.gov/pubmed/29427994
http://dx.doi.org/10.1186/s13045-018-0566-8
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author Wei, Hui
Wang, Ying
Zhou, Chunlin
Lin, Dong
Liu, Bingcheng
Liu, Kaiqi
Qiu, Shaowei
Gong, Benfa
Li, Yan
Zhang, Guangji
Wei, Shuning
Gong, Xiaoyuan
Liu, Yuntao
Zhao, Xingli
Gu, Runxia
Mi, Yingchang
Wang, Jianxiang
author_facet Wei, Hui
Wang, Ying
Zhou, Chunlin
Lin, Dong
Liu, Bingcheng
Liu, Kaiqi
Qiu, Shaowei
Gong, Benfa
Li, Yan
Zhang, Guangji
Wei, Shuning
Gong, Xiaoyuan
Liu, Yuntao
Zhao, Xingli
Gu, Runxia
Mi, Yingchang
Wang, Jianxiang
author_sort Wei, Hui
collection PubMed
description Racial and ethnic disparities in malignancies attract extensive attention. To investigate whether there are racial and ethnic disparities in genetic alteration between Caucasian and Eastern Asian population, data from several prospective AML trials were retrospectively analyzed in this study. We found that there were more patients with core binding factor (CBF) leukemia in Eastern Asian cohorts and there were different CBF leukemia constitutions between them. The ratios of CBF leukemia are 27.7, 22.1, 21.1, and 23.4%, respectively, in our (ChiCTR-TRC-10001202), another Chinese, Korean, and Japanese Eastern Asian cohorts, which are significantly higher than those in ECOG1900, MRC AML15, UK NCRI AML17, HOVON/SAKK AML-42, and German AML2003 (15.5, 12.5, 9.3, 10.2, and 12%, respectively). And CBFbeta-MYH11 occurred more prevalently in HOVON/SAKK AML- 42 and ECOG1900 trials (50.0 and 54.3% of CBF leukemia, respectively) than in Chinese and Japanese trials (20.1 and 20.8%, respectively). The proportion of FLT3-ITD mutation is 11.2% in our cohort, which is lower than that in MRC AML15 and UK NCRI AML17 (24.6 and 17.9%, respectively). Even after excluding the age bias, there are still different incidence rates of mutation between Caucasian and Eastern Asian population. These data suggest that there are racial and ethnic disparities in genetic alteration between Caucasian and Eastern Asian population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13045-018-0566-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-58078532018-02-15 Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population Wei, Hui Wang, Ying Zhou, Chunlin Lin, Dong Liu, Bingcheng Liu, Kaiqi Qiu, Shaowei Gong, Benfa Li, Yan Zhang, Guangji Wei, Shuning Gong, Xiaoyuan Liu, Yuntao Zhao, Xingli Gu, Runxia Mi, Yingchang Wang, Jianxiang J Hematol Oncol Letter to the Editor Racial and ethnic disparities in malignancies attract extensive attention. To investigate whether there are racial and ethnic disparities in genetic alteration between Caucasian and Eastern Asian population, data from several prospective AML trials were retrospectively analyzed in this study. We found that there were more patients with core binding factor (CBF) leukemia in Eastern Asian cohorts and there were different CBF leukemia constitutions between them. The ratios of CBF leukemia are 27.7, 22.1, 21.1, and 23.4%, respectively, in our (ChiCTR-TRC-10001202), another Chinese, Korean, and Japanese Eastern Asian cohorts, which are significantly higher than those in ECOG1900, MRC AML15, UK NCRI AML17, HOVON/SAKK AML-42, and German AML2003 (15.5, 12.5, 9.3, 10.2, and 12%, respectively). And CBFbeta-MYH11 occurred more prevalently in HOVON/SAKK AML- 42 and ECOG1900 trials (50.0 and 54.3% of CBF leukemia, respectively) than in Chinese and Japanese trials (20.1 and 20.8%, respectively). The proportion of FLT3-ITD mutation is 11.2% in our cohort, which is lower than that in MRC AML15 and UK NCRI AML17 (24.6 and 17.9%, respectively). Even after excluding the age bias, there are still different incidence rates of mutation between Caucasian and Eastern Asian population. These data suggest that there are racial and ethnic disparities in genetic alteration between Caucasian and Eastern Asian population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13045-018-0566-8) contains supplementary material, which is available to authorized users. BioMed Central 2018-02-10 /pmc/articles/PMC5807853/ /pubmed/29427994 http://dx.doi.org/10.1186/s13045-018-0566-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Wei, Hui
Wang, Ying
Zhou, Chunlin
Lin, Dong
Liu, Bingcheng
Liu, Kaiqi
Qiu, Shaowei
Gong, Benfa
Li, Yan
Zhang, Guangji
Wei, Shuning
Gong, Xiaoyuan
Liu, Yuntao
Zhao, Xingli
Gu, Runxia
Mi, Yingchang
Wang, Jianxiang
Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population
title Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population
title_full Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population
title_fullStr Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population
title_full_unstemmed Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population
title_short Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population
title_sort distinct genetic alteration profiles of acute myeloid leukemia between caucasian and eastern asian population
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807853/
https://www.ncbi.nlm.nih.gov/pubmed/29427994
http://dx.doi.org/10.1186/s13045-018-0566-8
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