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Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase

AIM: To investigate the effect of metformin on activated hepatic stellate cells (HSCs) and the possible signaling pathways involved. METHODS: A fibrotic mouse model was generated by intraperitoneal injection of carbon tetrachloride (CCl(4)) and subsequent treatment with or without metformin. The lev...

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Detalles Bibliográficos
Autores principales:	Li, Zhen, Ding, Qian, Ling, Li-Ping, Wu, Ying, Meng, Dong-Xiao, Li, Xiao, Zhang, Chun-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2018
Materias:	Basic Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807940/ https://www.ncbi.nlm.nih.gov/pubmed/29467552 http://dx.doi.org/10.3748/wjg.v24.i7.819

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