Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia

In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) account for up to 25% of cases and are associated with a poor outcome. In order to better target this AML subtype, a comprehensive view of how FLT3-ITD impacts AML cell biology is r...

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Detalles Bibliográficos
Autores principales: Heydt, Q, Larrue, C, Saland, E, Bertoli, S, Sarry, J-E, Besson, A, Manenti, S, Joffre, C, Mansat-De Mas, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808073/
https://www.ncbi.nlm.nih.gov/pubmed/29059168
http://dx.doi.org/10.1038/onc.2017.376

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