Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

The fms-related tyrosine kinase 3 (FLT3) receptor has been extensively studied over the past two decades with regard to oncogenic alterations that do not only serve as prognostic markers but also as therapeutic targets in acute myeloid leukemia (AML). Internal tandem duplications (ITDs) became of sp...

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Detalles Bibliográficos
Autores principales: Reiter, K, Polzer, H, Krupka, C, Maiser, A, Vick, B, Rothenberg-Thurley, M, Metzeler, K H, Dörfel, D, Salih, H R, Jung, G, Nößner, E, Jeremias, I, Hiddemann, W, Leonhardt, H, Spiekermann, K, Subklewe, M, Greif, P A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808080/
https://www.ncbi.nlm.nih.gov/pubmed/28895560
http://dx.doi.org/10.1038/leu.2017.257

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