Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress

Retinoic acid (RA) in association with chemotherapy or with arsenic trioxide (ATO) results in high cure rates of acute promyelocytic leukemia (APL). We show that RA-induced differentiation of human leukemic cell lines and primary blasts dramatically increases their sensitivity to endoplasmic reticul...

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Detalles Bibliográficos
Autores principales: Masciarelli, S, Capuano, E, Ottone, T, Divona, M, De Panfilis, S, Banella, C, Noguera, N I, Picardi, A, Fontemaggi, G, Blandino, G, Lo-Coco, F, Fazi, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808088/
https://www.ncbi.nlm.nih.gov/pubmed/28776567
http://dx.doi.org/10.1038/leu.2017.231

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