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Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron

The coexistence of neuronal activity regimes has been reported under normal and pathological conditions. Such multistability could enhance the flexibility of the nervous system and has many implications for motor control, memory, and decision making. Multistability is commonly promoted by neuromodul...

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Autores principales: Dashevskiy, Tatiana, Cymbalyuk, Gennady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808133/
https://www.ncbi.nlm.nih.gov/pubmed/29467641
http://dx.doi.org/10.3389/fncom.2018.00005
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author Dashevskiy, Tatiana
Cymbalyuk, Gennady
author_facet Dashevskiy, Tatiana
Cymbalyuk, Gennady
author_sort Dashevskiy, Tatiana
collection PubMed
description The coexistence of neuronal activity regimes has been reported under normal and pathological conditions. Such multistability could enhance the flexibility of the nervous system and has many implications for motor control, memory, and decision making. Multistability is commonly promoted by neuromodulation targeting specific membrane ionic currents. Here, we investigated how modulation of different ionic currents could affect the neuronal propensity for bistability. We considered a leech heart interneuron model. It exhibits bistability of bursting and silence in a narrow range of the leak current parameters, conductance (g(leak)) and reversal potential (E(leak)). We assessed the propensity for bistability of the model by using bifurcation diagrams. On the diagram (g(leak), E(leak)), we mapped bursting and silent regimes. For the canonical value of E(leak) we determined the range of g(leak) which supported the bistability. We use this range as an index of propensity for bistability. We investigated how this index was affected by alterations of ionic currents. We systematically changed their conductances, one at a time, and built corresponding bifurcation diagrams in parameter planes of the maximal conductance of a given current and the leak conductance. We found that conductance of only one current substantially affected the index of propensity; the increase of the maximal conductance of the hyperpolarization-activated cationic current increased the propensity index. The second conductance with the strongest effect was the conductance of the low-threshold fast Ca(2+) current; its reduction increased the propensity index although the effect was about two times smaller in magnitude. Analyzing the model with both changes applied simultaneously, we found that the diagram (g(leak), E(leak)) showed a progressively expanded area of bistability of bursting and silence.
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spelling pubmed-58081332018-02-21 Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron Dashevskiy, Tatiana Cymbalyuk, Gennady Front Comput Neurosci Neuroscience The coexistence of neuronal activity regimes has been reported under normal and pathological conditions. Such multistability could enhance the flexibility of the nervous system and has many implications for motor control, memory, and decision making. Multistability is commonly promoted by neuromodulation targeting specific membrane ionic currents. Here, we investigated how modulation of different ionic currents could affect the neuronal propensity for bistability. We considered a leech heart interneuron model. It exhibits bistability of bursting and silence in a narrow range of the leak current parameters, conductance (g(leak)) and reversal potential (E(leak)). We assessed the propensity for bistability of the model by using bifurcation diagrams. On the diagram (g(leak), E(leak)), we mapped bursting and silent regimes. For the canonical value of E(leak) we determined the range of g(leak) which supported the bistability. We use this range as an index of propensity for bistability. We investigated how this index was affected by alterations of ionic currents. We systematically changed their conductances, one at a time, and built corresponding bifurcation diagrams in parameter planes of the maximal conductance of a given current and the leak conductance. We found that conductance of only one current substantially affected the index of propensity; the increase of the maximal conductance of the hyperpolarization-activated cationic current increased the propensity index. The second conductance with the strongest effect was the conductance of the low-threshold fast Ca(2+) current; its reduction increased the propensity index although the effect was about two times smaller in magnitude. Analyzing the model with both changes applied simultaneously, we found that the diagram (g(leak), E(leak)) showed a progressively expanded area of bistability of bursting and silence. Frontiers Media S.A. 2018-02-06 /pmc/articles/PMC5808133/ /pubmed/29467641 http://dx.doi.org/10.3389/fncom.2018.00005 Text en Copyright © 2018 Dashevskiy and Cymbalyuk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Dashevskiy, Tatiana
Cymbalyuk, Gennady
Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron
title Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron
title_full Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron
title_fullStr Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron
title_full_unstemmed Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron
title_short Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron
title_sort propensity for bistability of bursting and silence in the leech heart interneuron
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808133/
https://www.ncbi.nlm.nih.gov/pubmed/29467641
http://dx.doi.org/10.3389/fncom.2018.00005
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