Immune Repertoire Sequencing Using Molecular Identifiers Enables Accurate Clonality Discovery and Clone Size Quantification

Unique molecular identifiers (MIDs) have been demonstrated to effectively improve immune repertoire sequencing (IR-seq) accuracy, especially to identify somatic hypermutations in antibody repertoire sequencing. However, evaluating the sensitivity to detect rare T cells and the degree of clonal expan...

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Detalles Bibliográficos
Autores principales: Ma, Ke-Yue, He, Chenfeng, Wendel, Ben S., Williams, Chad M., Xiao, Jun, Yang, Hui, Jiang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808239/
https://www.ncbi.nlm.nih.gov/pubmed/29467754
http://dx.doi.org/10.3389/fimmu.2018.00033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808239/
https://www.ncbi.nlm.nih.gov/pubmed/29467754
http://dx.doi.org/10.3389/fimmu.2018.00033

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