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Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness to Lipopolysaccharide

Tumor necrosis factor (TNF)-receptor-associated periodic fever syndrome (TRAPS) is a rare monogenic autoinflammatory disorder characterized by mutations in the TNFRSF1A gene, causing TNF-receptor 1 (TNFR1) misfolding, increased cellular stress, activation of the unfolded protein response (UPR), and...

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Detalles Bibliográficos
Autores principales:	Harrison, Stephanie R., Scambler, Thomas, Oubussad, Lylia, Wong, Chi, Wittmann, Miriam, McDermott, Michael F., Savic, Sinisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808292/ https://www.ncbi.nlm.nih.gov/pubmed/29467762 http://dx.doi.org/10.3389/fimmu.2018.00173

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