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Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints

Insomnia is characterized by sensory hypersensitivity and cognitive impairments. Recent work has identified the insula as a central brain region involved in both bottom-up gating of sensory information and top-down cognitive control. However, the specific relationships between insular subregion conn...

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Autores principales: Liu, Chun-Hong, Liu, Cun-Zhi, Zhu, Xue-Qi, Fang, Ji-Liang, Lu, Shun-Li, Tang, Li-Rong, Wang, Chuan-Yue, Liu, Qing-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808346/
https://www.ncbi.nlm.nih.gov/pubmed/29467636
http://dx.doi.org/10.3389/fnhum.2018.00035
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author Liu, Chun-Hong
Liu, Cun-Zhi
Zhu, Xue-Qi
Fang, Ji-Liang
Lu, Shun-Li
Tang, Li-Rong
Wang, Chuan-Yue
Liu, Qing-Quan
author_facet Liu, Chun-Hong
Liu, Cun-Zhi
Zhu, Xue-Qi
Fang, Ji-Liang
Lu, Shun-Li
Tang, Li-Rong
Wang, Chuan-Yue
Liu, Qing-Quan
author_sort Liu, Chun-Hong
collection PubMed
description Insomnia is characterized by sensory hypersensitivity and cognitive impairments. Recent work has identified the insula as a central brain region involved in both bottom-up gating of sensory information and top-down cognitive control. However, the specific relationships between insular subregion connectivity and emotional and cognitive functions remain unclear. In this study, resting-state functional magnetic resonance imaging data were obtained from 25 healthy participants with sleep complaints (HPS) and 25 age-, gender- and educational level-matched healthy participants without insomnia complaints (HP). We performed insular subregion (ventral anterior, dorsal anterior and posterior) functional connectivity (FC) analyses, and cognitive function was measured with several validated test procedures (e.g., the Wisconsin Card Sorting Test [WCST], Continuous Performance Test [CPT] and Trail making Test [TMT]). There were no significant differences between the two groups for WCST, CPT and TMT scores. The HPS group showed enhanced connectivity from the right posterior insula (R-PI) to the left postcentral gyrus (L-postCG) compared to HP group. WCST random errors (RE), sleep disturbance scores and HAMA scores correlated with this connectivity measurement in both HP and HPS groups. Our results provide direct evidence that the posterior insula (PI) synchronizes with sensorimotor areas to detect homeostatic changes and suggest that alteration of the latter is related to executive dysfunction in subjects with insomnia.
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spelling pubmed-58083462018-02-21 Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints Liu, Chun-Hong Liu, Cun-Zhi Zhu, Xue-Qi Fang, Ji-Liang Lu, Shun-Li Tang, Li-Rong Wang, Chuan-Yue Liu, Qing-Quan Front Hum Neurosci Neuroscience Insomnia is characterized by sensory hypersensitivity and cognitive impairments. Recent work has identified the insula as a central brain region involved in both bottom-up gating of sensory information and top-down cognitive control. However, the specific relationships between insular subregion connectivity and emotional and cognitive functions remain unclear. In this study, resting-state functional magnetic resonance imaging data were obtained from 25 healthy participants with sleep complaints (HPS) and 25 age-, gender- and educational level-matched healthy participants without insomnia complaints (HP). We performed insular subregion (ventral anterior, dorsal anterior and posterior) functional connectivity (FC) analyses, and cognitive function was measured with several validated test procedures (e.g., the Wisconsin Card Sorting Test [WCST], Continuous Performance Test [CPT] and Trail making Test [TMT]). There were no significant differences between the two groups for WCST, CPT and TMT scores. The HPS group showed enhanced connectivity from the right posterior insula (R-PI) to the left postcentral gyrus (L-postCG) compared to HP group. WCST random errors (RE), sleep disturbance scores and HAMA scores correlated with this connectivity measurement in both HP and HPS groups. Our results provide direct evidence that the posterior insula (PI) synchronizes with sensorimotor areas to detect homeostatic changes and suggest that alteration of the latter is related to executive dysfunction in subjects with insomnia. Frontiers Media S.A. 2018-02-07 /pmc/articles/PMC5808346/ /pubmed/29467636 http://dx.doi.org/10.3389/fnhum.2018.00035 Text en Copyright © 2018 Liu, Liu, Zhu, Fang, Lu, Tang, Wang and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Chun-Hong
Liu, Cun-Zhi
Zhu, Xue-Qi
Fang, Ji-Liang
Lu, Shun-Li
Tang, Li-Rong
Wang, Chuan-Yue
Liu, Qing-Quan
Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints
title Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints
title_full Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints
title_fullStr Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints
title_full_unstemmed Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints
title_short Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints
title_sort increased posterior insula-sensorimotor connectivity is associated with cognitive function in healthy participants with sleep complaints
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808346/
https://www.ncbi.nlm.nih.gov/pubmed/29467636
http://dx.doi.org/10.3389/fnhum.2018.00035
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