Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

[Image: see text] PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes and has been implicated in several diseases. We recently disclosed a highly potent, selective, and cell-active allosteric inhibitor of PRMT3, compound 4....

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Detalles Bibliográficos
Autores principales: Kaniskan, H. Ümit, Eram, Mohammad S., Zhao, Kehao, Szewczyk, Magdalena M., Yang, Xiaobao, Schmidt, Keith, Luo, Xiao, Xiao, Sean, Dai, Miao, He, Feng, Zang, Irene, Lin, Ying, Li, Fengling, Dobrovetsky, Elena, Smil, David, Min, Sun-Joon, Lin-Jones, Jennifer, Schapira, Matthieu, Atadja, Peter, Li, En, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Feng, Yu, Zhengtian, Vedadi, Masoud, Jin, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808361/
https://www.ncbi.nlm.nih.gov/pubmed/29244490
http://dx.doi.org/10.1021/acs.jmedchem.7b01674

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