Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets

[Image: see text] Chemical modifications of 2′-O-methyl (2′-OMe) and locked nucleic acid (LNA) of the nucleotides in the seed region (positions 2–8) of the small interfering RNA (siRNA) guide strand significantly reduced seed-matched (SM) off-target effects. The siRNA with 2′-OMe modifications inhib...

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Detalles Bibliográficos
Autores principales: Iribe, Hanna, Miyamoto, Kengo, Takahashi, Tomoko, Kobayashi, Yoshiaki, Leo, Jastina, Aida, Misako, Ui-Tei, Kumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808362/
https://www.ncbi.nlm.nih.gov/pubmed/29450406
http://dx.doi.org/10.1021/acsomega.7b00291

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