Molecular mechanisms underlying the impact of mutations in SOD1 on its conformational properties associated with amyotrophic lateral sclerosis as revealed with molecular modelling

BACKGROUND: So far, little is known about the molecular mechanisms of amyotrophic lateral sclerosis onset and progression caused by SOD1 mutations. One of the hypotheses is based on SOD1 misfolding resulting from mutations and subsequent deposition of its cytotoxic aggregates. This hypothesis is com...

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Detalles Bibliográficos
Autores principales: Alemasov, Nikolay A., Ivanisenko, Nikita V., Ramachandran, Srinivasan, Ivanisenko, Vladimir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808480/
https://www.ncbi.nlm.nih.gov/pubmed/29431095
http://dx.doi.org/10.1186/s12900-018-0080-9

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