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Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease

BACKGROUND AND OBJECTIVES: Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The...

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Autores principales: Hu, Xianwei, Wang, Haibao, Tu, Youhui, Fei, Mengdi, Yin, Minmin, Fei, Guanghe, Yu, Yongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808710/
https://www.ncbi.nlm.nih.gov/pubmed/29445270
http://dx.doi.org/10.2147/COPD.S146870
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author Hu, Xianwei
Wang, Haibao
Tu, Youhui
Fei, Mengdi
Yin, Minmin
Fei, Guanghe
Yu, Yongqiang
author_facet Hu, Xianwei
Wang, Haibao
Tu, Youhui
Fei, Mengdi
Yin, Minmin
Fei, Guanghe
Yu, Yongqiang
author_sort Hu, Xianwei
collection PubMed
description BACKGROUND AND OBJECTIVES: Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The aim of this study was to investigate the correlations between cognition and function changes of the DMN in COPD patients. METHODS: One hundred and thirteen eligible participants including 30 control subjects and 83 COPD patients matched for demographic characteristics were recruited. All participants performed cognitive function tests and underwent resting state functional magnetic resonance imaging. RESULTS: The total cognitive function scores of COPD patients were significantly different from those of control subjects (P<0.05) and worsened with the degree of airflow obstruction. The activated brain regions in the DMN of COPD patients were less than those of normal controls. Six activated brain regions in the DMN were found to develop significantly different functional connectivity (FC) values among the subjects. Meanwhile, the FC values of the left posterior cingulate cortex and left hippocampus correlated well with cognitive functions and pulmonary function. CONCLUSION: COPD patients have cognitive impairments that correlate well with disease severity. FC changes in activated brain regions in the DMN may predict cognitive impairment, and the left posterior cingulate cortex and left hippocampus may be important brain regions related to cognitive impairment in COPD patients.
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spelling pubmed-58087102018-02-14 Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease Hu, Xianwei Wang, Haibao Tu, Youhui Fei, Mengdi Yin, Minmin Fei, Guanghe Yu, Yongqiang Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND AND OBJECTIVES: Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The aim of this study was to investigate the correlations between cognition and function changes of the DMN in COPD patients. METHODS: One hundred and thirteen eligible participants including 30 control subjects and 83 COPD patients matched for demographic characteristics were recruited. All participants performed cognitive function tests and underwent resting state functional magnetic resonance imaging. RESULTS: The total cognitive function scores of COPD patients were significantly different from those of control subjects (P<0.05) and worsened with the degree of airflow obstruction. The activated brain regions in the DMN of COPD patients were less than those of normal controls. Six activated brain regions in the DMN were found to develop significantly different functional connectivity (FC) values among the subjects. Meanwhile, the FC values of the left posterior cingulate cortex and left hippocampus correlated well with cognitive functions and pulmonary function. CONCLUSION: COPD patients have cognitive impairments that correlate well with disease severity. FC changes in activated brain regions in the DMN may predict cognitive impairment, and the left posterior cingulate cortex and left hippocampus may be important brain regions related to cognitive impairment in COPD patients. Dove Medical Press 2018-02-07 /pmc/articles/PMC5808710/ /pubmed/29445270 http://dx.doi.org/10.2147/COPD.S146870 Text en © 2018 Hu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Hu, Xianwei
Wang, Haibao
Tu, Youhui
Fei, Mengdi
Yin, Minmin
Fei, Guanghe
Yu, Yongqiang
Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
title Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
title_full Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
title_fullStr Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
title_full_unstemmed Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
title_short Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
title_sort alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808710/
https://www.ncbi.nlm.nih.gov/pubmed/29445270
http://dx.doi.org/10.2147/COPD.S146870
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