Genome-editing applications of CRISPR–Cas9 to promote in vitro studies of Alzheimer’s disease

Genetic variations play an important role in the clinical presentation and progression of Alzheimer’s disease (AD), especially early-onset Alzheimer’s disease. Hundreds of mutations have been reported with the majority resulting from alterations in β-amyloid precursor protein (APP), presenilin 1 (PS...

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Detalles Bibliográficos
Autores principales: Giau, Vo Van, Lee, Hyon, Shim, Kyu Hwan, Bagyinszky, Eva, An, Seong Soo A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808714/
https://www.ncbi.nlm.nih.gov/pubmed/29445268
http://dx.doi.org/10.2147/CIA.S155145

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