A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell

Rheumatoid arthritis (RA) is a chronic polyarthritis of unknown etiology. To unravel the molecular mechanisms in RA, we performed targeted DNA sequencing analysis of patients with RA. This analysis identified a variant of the death receptor 3 (DR3) gene, a member of the family of apoptosis-inducing...

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Detalles Bibliográficos
Autores principales: Hashiramoto, Akira, Konishi, Yoshitake, Murayama, Koichi, Kawasaki, Hiroki, Yoshida, Kohsuke, Tsumiyama, Ken, Tanaka, Kimie, Mizuhara, Masaru, Shiotsuki, Toshio, Kitamura, Hitomi, Komai, Koichiro, Kimura, Tomoatsu, Yagita, Hideo, Shiozawa, Kazuko, Shiozawa, Shunichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808757/
https://www.ncbi.nlm.nih.gov/pubmed/29180447
http://dx.doi.org/10.1074/jbc.M117.798884

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