Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome

We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)–1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated w...

Descripción completa

Detalles Bibliográficos
Autores principales: Bellomo, Carla, Korva, Miša, Papa, Anna, Mäkelä, Satu, Mustonen, Jukka, Avšič-Županc, Tatjana, Vaheri, Antti, Martinez, Valeria P, Strandin, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808793/
https://www.ncbi.nlm.nih.gov/pubmed/29450213
http://dx.doi.org/10.1093/ofid/ofy021
Descripción
Sumario:We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)–1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.

Ejemplares similares