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Reactive Oxygen Species: A Key Constituent in Cancer Survival
BACKGROUND: Cancer is one of the major heterogeneous disease with high morbidity and mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in redox balance, and deregulated redox signaling are common hallmarks of cancer progression and resistance to treatment. M...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808965/ https://www.ncbi.nlm.nih.gov/pubmed/29449774 http://dx.doi.org/10.1177/1177271918755391 |
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author | Kumari, Seema Badana, Anil Kumar G, Murali Mohan G, Shailender Malla, RamaRao |
author_facet | Kumari, Seema Badana, Anil Kumar G, Murali Mohan G, Shailender Malla, RamaRao |
author_sort | Kumari, Seema |
collection | PubMed |
description | BACKGROUND: Cancer is one of the major heterogeneous disease with high morbidity and mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in redox balance, and deregulated redox signaling are common hallmarks of cancer progression and resistance to treatment. Mitochondria contribute mainly in the generation of ROS during oxidative phosphorylation. Elevated levels of ROS have been detected in cancers cells due to high metabolic activity, cellular signaling, peroxisomal activity, mitochondrial dysfunction, activation of oncogene, and increased enzymatic activity of oxidases, cyclooxygenases, lipoxygenases, and thymidine phosphorylases. Cells maintain intracellular homeostasis by developing an immense antioxidant system including catalase, superoxide dismutase, and glutathione peroxidase. Besides these enzymes exist an important antioxidant glutathione and transcription factor Nrf2 which contribute in balancing oxidative stress. Reactive oxygen species–mediated signaling pathways activate pro-oncogenic signaling which eases in cancer progression, angiogenesis, and survival. Concomitantly, to maintain ROS homeostasis and evade cancer cell death, an increased level of antioxidant capacity is associated with cancer cells. CONCLUSIONS: This review focuses the role of ROS in cancer survival pathways and importance of targeting the ROS signal involved in cancer development, which is a new strategy in cancer treatment. |
format | Online Article Text |
id | pubmed-5808965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-58089652018-02-15 Reactive Oxygen Species: A Key Constituent in Cancer Survival Kumari, Seema Badana, Anil Kumar G, Murali Mohan G, Shailender Malla, RamaRao Biomark Insights Review BACKGROUND: Cancer is one of the major heterogeneous disease with high morbidity and mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in redox balance, and deregulated redox signaling are common hallmarks of cancer progression and resistance to treatment. Mitochondria contribute mainly in the generation of ROS during oxidative phosphorylation. Elevated levels of ROS have been detected in cancers cells due to high metabolic activity, cellular signaling, peroxisomal activity, mitochondrial dysfunction, activation of oncogene, and increased enzymatic activity of oxidases, cyclooxygenases, lipoxygenases, and thymidine phosphorylases. Cells maintain intracellular homeostasis by developing an immense antioxidant system including catalase, superoxide dismutase, and glutathione peroxidase. Besides these enzymes exist an important antioxidant glutathione and transcription factor Nrf2 which contribute in balancing oxidative stress. Reactive oxygen species–mediated signaling pathways activate pro-oncogenic signaling which eases in cancer progression, angiogenesis, and survival. Concomitantly, to maintain ROS homeostasis and evade cancer cell death, an increased level of antioxidant capacity is associated with cancer cells. CONCLUSIONS: This review focuses the role of ROS in cancer survival pathways and importance of targeting the ROS signal involved in cancer development, which is a new strategy in cancer treatment. SAGE Publications 2018-02-06 /pmc/articles/PMC5808965/ /pubmed/29449774 http://dx.doi.org/10.1177/1177271918755391 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Kumari, Seema Badana, Anil Kumar G, Murali Mohan G, Shailender Malla, RamaRao Reactive Oxygen Species: A Key Constituent in Cancer Survival |
title | Reactive Oxygen Species: A Key Constituent in Cancer Survival |
title_full | Reactive Oxygen Species: A Key Constituent in Cancer Survival |
title_fullStr | Reactive Oxygen Species: A Key Constituent in Cancer Survival |
title_full_unstemmed | Reactive Oxygen Species: A Key Constituent in Cancer Survival |
title_short | Reactive Oxygen Species: A Key Constituent in Cancer Survival |
title_sort | reactive oxygen species: a key constituent in cancer survival |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808965/ https://www.ncbi.nlm.nih.gov/pubmed/29449774 http://dx.doi.org/10.1177/1177271918755391 |
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