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Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats
Hippocampal theta oscillations have been implicated in working memory and attentional process, which might be useful for the brain-machine interface (BMI). To further elucidate the properties of the hippocampal theta oscillations that can be used in BMI, we investigated hippocampal theta oscillation...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809047/ https://www.ncbi.nlm.nih.gov/pubmed/29432436 http://dx.doi.org/10.1371/journal.pone.0192593 |
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author | Tanaka, Norifumi Sano, Katsunari Rahman, Md Ashrafur Miyata, Ryota Capi, Genci Kawahara, Shigenori |
author_facet | Tanaka, Norifumi Sano, Katsunari Rahman, Md Ashrafur Miyata, Ryota Capi, Genci Kawahara, Shigenori |
author_sort | Tanaka, Norifumi |
collection | PubMed |
description | Hippocampal theta oscillations have been implicated in working memory and attentional process, which might be useful for the brain-machine interface (BMI). To further elucidate the properties of the hippocampal theta oscillations that can be used in BMI, we investigated hippocampal theta oscillations during a two-lever choice task. During the task body-restrained rats were trained with a food reward to move an e-puck robot towards them by pressing the correct lever, ipsilateral to the robot several times, using the ipsilateral forelimb. The robot carried food and moved along a semicircle track set in front of the rat. We demonstrated that the power of hippocampal theta oscillations gradually increased during a 6-s preparatory period before the start of multiple lever pressing, irrespective of whether the correct lever choice or forelimb side were used. In addition, there was a significant difference in the theta power after the first choice, between correct and incorrect trials. During the correct trials the theta power was highest during the first lever-releasing period, whereas in the incorrect trials it occurred during the second correct lever-pressing period. We also analyzed the hippocampal theta oscillations at the termination of multiple lever pressing during the correct trials. Irrespective of whether the correct forelimb side was used, the power of hippocampal theta oscillations gradually decreased with the termination of multiple lever pressing. The frequency of theta oscillation also demonstrated an increase and decrease, before and after multiple lever pressing, respectively. There was a transient increase in frequency after the first lever press during the incorrect trials, while no such increase was observed during the correct trials. These results suggested that hippocampal theta oscillations reflect some aspects of preparatory and cognitive neural activities during the robot controlling task, which could be used for BMI. |
format | Online Article Text |
id | pubmed-5809047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58090472018-02-28 Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats Tanaka, Norifumi Sano, Katsunari Rahman, Md Ashrafur Miyata, Ryota Capi, Genci Kawahara, Shigenori PLoS One Research Article Hippocampal theta oscillations have been implicated in working memory and attentional process, which might be useful for the brain-machine interface (BMI). To further elucidate the properties of the hippocampal theta oscillations that can be used in BMI, we investigated hippocampal theta oscillations during a two-lever choice task. During the task body-restrained rats were trained with a food reward to move an e-puck robot towards them by pressing the correct lever, ipsilateral to the robot several times, using the ipsilateral forelimb. The robot carried food and moved along a semicircle track set in front of the rat. We demonstrated that the power of hippocampal theta oscillations gradually increased during a 6-s preparatory period before the start of multiple lever pressing, irrespective of whether the correct lever choice or forelimb side were used. In addition, there was a significant difference in the theta power after the first choice, between correct and incorrect trials. During the correct trials the theta power was highest during the first lever-releasing period, whereas in the incorrect trials it occurred during the second correct lever-pressing period. We also analyzed the hippocampal theta oscillations at the termination of multiple lever pressing during the correct trials. Irrespective of whether the correct forelimb side was used, the power of hippocampal theta oscillations gradually decreased with the termination of multiple lever pressing. The frequency of theta oscillation also demonstrated an increase and decrease, before and after multiple lever pressing, respectively. There was a transient increase in frequency after the first lever press during the incorrect trials, while no such increase was observed during the correct trials. These results suggested that hippocampal theta oscillations reflect some aspects of preparatory and cognitive neural activities during the robot controlling task, which could be used for BMI. Public Library of Science 2018-02-12 /pmc/articles/PMC5809047/ /pubmed/29432436 http://dx.doi.org/10.1371/journal.pone.0192593 Text en © 2018 Tanaka et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Tanaka, Norifumi Sano, Katsunari Rahman, Md Ashrafur Miyata, Ryota Capi, Genci Kawahara, Shigenori Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats |
title | Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats |
title_full | Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats |
title_fullStr | Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats |
title_full_unstemmed | Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats |
title_short | Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats |
title_sort | change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809047/ https://www.ncbi.nlm.nih.gov/pubmed/29432436 http://dx.doi.org/10.1371/journal.pone.0192593 |
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