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Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis

Cathepsin B (CatB) is a cysteine proteolytic enzyme widely expressed in various cells and mainly located in the lysosomes. It contributes to the pathogenesis and development of many diseases. However, the role of CatB in viral myocarditis (VMC) has never been elucidated. Here we generated the VMC mo...

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Detalles Bibliográficos
Autores principales:	Wang, Yaping, Jia, Liangliang, Shen, Jian, Wang, Yidong, Fu, Zurong, Su, Sheng-an, Cai, Zhejun, Wang, Jian-an, Xiang, Meixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809100/ https://www.ncbi.nlm.nih.gov/pubmed/29360865 http://dx.doi.org/10.1371/journal.ppat.1006872

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