Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture

BACKGROUND AIMS: Spontaneous mutagenesis often leads to appearance of genetic changes in cells. Although human multipotent mesenchymal stromal cells (hMSC) are considered as genetically stable, there is a risk of genomic and structural chromosome instability and, therefore, side effects of cell ther...

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Detalles Bibliográficos
Autores principales: Nikitina, Victoria, Astrelina, Tatiana, Nugis, Vladimir, Ostashkin, Aleksandr, Karaseva, Tatiana, Dobrovolskaya, Ekaterina, Usupzhanova, Dariya, Suchkova, Yulia, Lomonosova, Elena, Rodin, Sergey, Brunchukov, Vitaliy, Lauk-Dubitskiy, Stanislav, Brumberg, Valentin, Machova, Anastasia, Kobzeva, Irina, Bushmanov, Andrey, Samoilov, Aleksandr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809118/
https://www.ncbi.nlm.nih.gov/pubmed/29432491
http://dx.doi.org/10.1371/journal.pone.0192445

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