Cargando…

LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer

Current understanding of aggressive human basal-like triple-negative breast cancer (TNBC) remains incomplete. In this study, we show endothelial lipase (LIPG) is aberrantly overexpressed in basal-like TNBCs. We demonstrate that LIPG is required for in vivo tumorigenicity and metastasis of TNBC cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lo, Pang-Kuo, Yao, Yuan, Lee, Ji Shin, Zhang, Yongshu, Huang, Weiliang, Kane, Maureen A, Zhou, Qun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809145/ https://www.ncbi.nlm.nih.gov/pubmed/29350614 http://dx.doi.org/10.7554/eLife.31334

Ejemplares similares

Inhibition of LIPG phospholipase activity suppresses tumor formation of human basal-like triple-negative breast cancer
por: Lo, Pang-Kuo, et al.
Publicado: (2020)

LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer
por: Cadenas, Cristina, et al.
Publicado: (2019)

Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis
por: Weichhaus, Michael, et al.
Publicado: (2014)

OSW‐1 inhibits tumor growth and metastasis by NFATc2 on triple‐negative breast cancer
por: Ding, Xiaorong, et al.
Publicado: (2020)

EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry
por: Luan, Haitao, et al.
Publicado: (2023)

Fascin‐1 as a novel diagnostic marker of triple‐negative breast cancer
por: Wang, Chao‐Qun, et al.
Publicado: (2016)

LIPG supports adaption to oxidative stress
por: Leonhardt, Gregor
Publicado: (2019)

5‐Chloro‐2,4‐dihydroxypyridine, CDHP, prevents lung metastasis of basal‐like breast cancer cells by reducing nascent adhesion formation
por: Itou, Junji, et al.
Publicado: (2018)

MELK is not necessary for the proliferation of basal-like breast cancer cells
por: Huang, Hai-Tsang, et al.
Publicado: (2017)

Two activating mutations of MPL in triple‐negative myeloproliferative neoplasms
por: Xie, Juan, et al.
Publicado: (2019)

The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
por: Zhang, Haomeng, et al.
Publicado: (2021)

Fangjihuangqi Decoction inhibits MDA‐MB‐231 cell invasion in vitro and decreases tumor growth and metastasis in triple‐negative breast cancer xenografts tumor zebrafish model
por: Guo, Yubo, et al.
Publicado: (2020)

Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers
por: Soyama, Hirotoshi, et al.
Publicado: (2022)

Characterization of the CD49f(+)/CD44(+)/CD24(−) single-cell derived stem cell population in basal-like DCIS cells
por: Duru, Nadire, et al.
Publicado: (2016)

Axon-like protrusions promote small cell lung cancer migration and metastasis
por: Yang, Dian, et al.
Publicado: (2019)

Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers
por: Vinet, Mathilde, et al.
Publicado: (2019)

ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer
por: Fang, Wentong, et al.
Publicado: (2021)

LIPG endothelial lipase and breast cancer risk by subtypes
por: Gago-Dominguez, Manuela, et al.
Publicado: (2021)

Effects of human arylamine N-acetyltransferase I knockdown in triple-negative breast cancer cell lines
por: Tiang, Jacky M, et al.
Publicado: (2015)

Development and characterization of two human triple‐negative breast cancer cell lines with highly tumorigenic and metastatic capabilities
por: Su, Yanrong, et al.
Publicado: (2016)

RECQL5 plays an essential role in maintaining genome stability and viability of triple‐negative breast cancer cells
por: Peng, Jin, et al.
Publicado: (2019)

SALL4 ‐ KHDRBS3 network enhances stemness by modulating CD44 splicing in basal‐like breast cancer
por: Matsumoto, Yoshiaki, et al.
Publicado: (2018)

Identification of tRNA‐derived small noncoding RNAs as potential biomarkers for prediction of recurrence in triple‐negative breast cancer
por: Feng, Wanting, et al.
Publicado: (2018)

Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression
por: Siddharth, Sumit, et al.
Publicado: (2021)

Are Basal-Like and Non-Basal-Like Triple-Negative Breast Cancers Really Different?
por: Dogra, Atika, et al.
Publicado: (2020)

The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
por: Gibbs, Zane A, et al.
Publicado: (2020)

The physiological characteristics of the basal microvilli microvessels in pancreatic cancers
por: Ma, Lixiang, et al.
Publicado: (2020)

Integrated analysis of DNA methylome and transcriptome reveals SFRP1 and LIPG as potential drivers of ovarian cancer metastasis
por: Yi, Jiani, et al.
Publicado: (2023)

Cancer stem cells are prevalent in the basal-like 2 and mesenchymal triple-negative breast cancer subtypes in vitro
por: Olsson, Maxim, et al.
Publicado: (2023)

Cancer stem cells and early stage basal-like breast cancer
por: Lo, Pang-Kuo, et al.
Publicado: (2016)

LIPG SNPs, their haplotypes and gene-environment interactions on serum lipid levels
por: Yang, Shuo, et al.
Publicado: (2019)

Epidermal growth factor‐containing fibulin‐like extracellular matrix protein 1 (EFEMP1) suppressed the growth of hepatocellular carcinoma cells by promoting Semaphorin 3B(SEMA3B)
por: Hu, Jiangfeng, et al.
Publicado: (2019)

Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
por: Fang, Huan, et al.
Publicado: (2023)

Impact of histotypes on preferential organ‐specific metastasis in triple‐negative breast cancer
por: Li, Yaming, et al.
Publicado: (2019)

Are triple-negative tumours and basal-like breast cancer synonymous?
por: Rakha, Emad A, et al.
Publicado: (2007)

Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers
por: Abd El-Aziz, Yomna S., et al.
Publicado: (2021)

Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis
por: Liao, Peng, et al.
Publicado: (2017)

LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR‐219a‐5p
por: Wang, Lihong, et al.
Publicado: (2019)

Correction: Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis
por: Liao, Peng, et al.
Publicado: (2017)

LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling
por: Santucci, Pierre, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8847fuo1ptihbe8p9q5qlfcp8k