Cargando…
Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
Subtle semantic deficits can be observed in Alzheimer’s disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-s...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809186/ https://www.ncbi.nlm.nih.gov/pubmed/29197559 http://dx.doi.org/10.1016/j.neuroscience.2017.11.030 |
_version_ | 1783299539330924544 |
---|---|
author | Mascali, Daniele DiNuzzo, Mauro Serra, Laura Mangia, Silvia Maraviglia, Bruno Bozzali, Marco Giove, Federico |
author_facet | Mascali, Daniele DiNuzzo, Mauro Serra, Laura Mangia, Silvia Maraviglia, Bruno Bozzali, Marco Giove, Federico |
author_sort | Mascali, Daniele |
collection | PubMed |
description | Subtle semantic deficits can be observed in Alzheimer’s disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n = 38; mean mini-mental state examination = 20.5) and in a group of age-matched healthy controls (n = 19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke’s area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing. |
format | Online Article Text |
id | pubmed-5809186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-58091862018-02-12 Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI Mascali, Daniele DiNuzzo, Mauro Serra, Laura Mangia, Silvia Maraviglia, Bruno Bozzali, Marco Giove, Federico Neuroscience Article Subtle semantic deficits can be observed in Alzheimer’s disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n = 38; mean mini-mental state examination = 20.5) and in a group of age-matched healthy controls (n = 19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke’s area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing. 2017-12-02 2018-02-10 /pmc/articles/PMC5809186/ /pubmed/29197559 http://dx.doi.org/10.1016/j.neuroscience.2017.11.030 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Mascali, Daniele DiNuzzo, Mauro Serra, Laura Mangia, Silvia Maraviglia, Bruno Bozzali, Marco Giove, Federico Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI |
title | Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI |
title_full | Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI |
title_fullStr | Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI |
title_full_unstemmed | Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI |
title_short | Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI |
title_sort | disruption of semantic network in mild alzheimer’s disease revealed by resting-state fmri |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809186/ https://www.ncbi.nlm.nih.gov/pubmed/29197559 http://dx.doi.org/10.1016/j.neuroscience.2017.11.030 |
work_keys_str_mv | AT mascalidaniele disruptionofsemanticnetworkinmildalzheimersdiseaserevealedbyrestingstatefmri AT dinuzzomauro disruptionofsemanticnetworkinmildalzheimersdiseaserevealedbyrestingstatefmri AT serralaura disruptionofsemanticnetworkinmildalzheimersdiseaserevealedbyrestingstatefmri AT mangiasilvia disruptionofsemanticnetworkinmildalzheimersdiseaserevealedbyrestingstatefmri AT maravigliabruno disruptionofsemanticnetworkinmildalzheimersdiseaserevealedbyrestingstatefmri AT bozzalimarco disruptionofsemanticnetworkinmildalzheimersdiseaserevealedbyrestingstatefmri AT giovefederico disruptionofsemanticnetworkinmildalzheimersdiseaserevealedbyrestingstatefmri |