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Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI

Subtle semantic deficits can be observed in Alzheimer’s disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-s...

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Autores principales: Mascali, Daniele, DiNuzzo, Mauro, Serra, Laura, Mangia, Silvia, Maraviglia, Bruno, Bozzali, Marco, Giove, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809186/
https://www.ncbi.nlm.nih.gov/pubmed/29197559
http://dx.doi.org/10.1016/j.neuroscience.2017.11.030
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author Mascali, Daniele
DiNuzzo, Mauro
Serra, Laura
Mangia, Silvia
Maraviglia, Bruno
Bozzali, Marco
Giove, Federico
author_facet Mascali, Daniele
DiNuzzo, Mauro
Serra, Laura
Mangia, Silvia
Maraviglia, Bruno
Bozzali, Marco
Giove, Federico
author_sort Mascali, Daniele
collection PubMed
description Subtle semantic deficits can be observed in Alzheimer’s disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n = 38; mean mini-mental state examination = 20.5) and in a group of age-matched healthy controls (n = 19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke’s area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing.
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spelling pubmed-58091862018-02-12 Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI Mascali, Daniele DiNuzzo, Mauro Serra, Laura Mangia, Silvia Maraviglia, Bruno Bozzali, Marco Giove, Federico Neuroscience Article Subtle semantic deficits can be observed in Alzheimer’s disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n = 38; mean mini-mental state examination = 20.5) and in a group of age-matched healthy controls (n = 19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke’s area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing. 2017-12-02 2018-02-10 /pmc/articles/PMC5809186/ /pubmed/29197559 http://dx.doi.org/10.1016/j.neuroscience.2017.11.030 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Mascali, Daniele
DiNuzzo, Mauro
Serra, Laura
Mangia, Silvia
Maraviglia, Bruno
Bozzali, Marco
Giove, Federico
Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
title Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
title_full Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
title_fullStr Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
title_full_unstemmed Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
title_short Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
title_sort disruption of semantic network in mild alzheimer’s disease revealed by resting-state fmri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809186/
https://www.ncbi.nlm.nih.gov/pubmed/29197559
http://dx.doi.org/10.1016/j.neuroscience.2017.11.030
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