Streptomyces sp metabolite(s) promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines

In cervical cancer, the association between HPV infection and dysregulation of phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway (PI3K/AKT/mTOR pathway) places mTOR as an attractive therapeutic target. The failure of current treatment modalities in...

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Detalles Bibliográficos
Autores principales: Dan, Vipin Mohan, Muralikrishnan, Balaji, Sanawar, Rahul, J. S., Vinodh, Burkul, Bhushan Bapusaheb, Srinivas, Kalanghad Puthankalam, Lekshmi, Asha, Pradeep, N. S., Dastager, Syed G., Santhakumari, B., Santhoshkumar, Thankayyan R., Kumar, R. Ajay, Pillai, Madhavan Radhakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809390/
https://www.ncbi.nlm.nih.gov/pubmed/29434241
http://dx.doi.org/10.1038/s41598-018-21249-5

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