CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

CD44 variant (CD44v) contributes to cancer stemness by stabilizing the xCT subunit of system xc(−) and thereby promoting its glutamate-cystine antiporter activity. CD44 has also been implicated in autoimmune insulitis and inflammation in diabetic islets, but whether CD44v regulates insulin secretion...

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Detalles Bibliográficos
Autores principales: Kobayashi, Nana, Okazaki, Shogo, Sampetrean, Oltea, Irie, Junichiro, Itoh, Hiroshi, Saya, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809395/
https://www.ncbi.nlm.nih.gov/pubmed/29434323
http://dx.doi.org/10.1038/s41598-018-20973-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809395/
https://www.ncbi.nlm.nih.gov/pubmed/29434323
http://dx.doi.org/10.1038/s41598-018-20973-2

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