The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events

Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular proces...

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Autores principales: Zhao, Yang, Dunker, William, Yu, Yi-Tao, Karijolich, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809436/
https://www.ncbi.nlm.nih.gov/pubmed/29473035
http://dx.doi.org/10.3389/fbioe.2018.00008
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author Zhao, Yang
Dunker, William
Yu, Yi-Tao
Karijolich, John
author_facet Zhao, Yang
Dunker, William
Yu, Yi-Tao
Karijolich, John
author_sort Zhao, Yang
collection PubMed
description Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular processes. The investigation of nuclear-ncRNA pseudouridylation has demonstrated that it is critical for the proper control of multiple stages of gene expression regulation. Here, we review how nuclear-ncRNA pseudouridylation contributes to transcriptional regulation and pre-mRNA splicing.
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spelling pubmed-58094362018-02-22 The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events Zhao, Yang Dunker, William Yu, Yi-Tao Karijolich, John Front Bioeng Biotechnol Bioengineering and Biotechnology Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular processes. The investigation of nuclear-ncRNA pseudouridylation has demonstrated that it is critical for the proper control of multiple stages of gene expression regulation. Here, we review how nuclear-ncRNA pseudouridylation contributes to transcriptional regulation and pre-mRNA splicing. Frontiers Media S.A. 2018-02-08 /pmc/articles/PMC5809436/ /pubmed/29473035 http://dx.doi.org/10.3389/fbioe.2018.00008 Text en Copyright © 2018 Zhao, Dunker, Yu and Karijolich. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zhao, Yang
Dunker, William
Yu, Yi-Tao
Karijolich, John
The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events
title The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events
title_full The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events
title_fullStr The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events
title_full_unstemmed The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events
title_short The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events
title_sort role of noncoding rna pseudouridylation in nuclear gene expression events
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809436/
https://www.ncbi.nlm.nih.gov/pubmed/29473035
http://dx.doi.org/10.3389/fbioe.2018.00008
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