Eliminating Factor H-Binding Activity of Borrelia burgdorferi CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine

The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, the most common tick-borne disease in the US and Europe. No potent human vaccine is currently available. The innate immune complement system is vital to host defense against pathogens, as complement activation on the surface...

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Detalles Bibliográficos
Autores principales: Marcinkiewicz, Ashley L., Lieknina, Ilva, Kotelovica, Svetlana, Yang, Xiuli, Kraiczy, Peter, Pal, Utpal, Lin, Yi-Pin, Tars, Kaspars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809437/
https://www.ncbi.nlm.nih.gov/pubmed/29472926
http://dx.doi.org/10.3389/fimmu.2018.00181

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