The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double transgenic mouse model, Akimba (Ins2(Akita)xVEGF(+/−)), which demonstrates hyperglycemia, vascular hyperpermeability and neov...

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Detalles Bibliográficos
Autores principales: Chaurasia, Shyam S., Lim, Rayne R., Parikh, Bhav H., Wey, Yeo Sia, Tun, Bo Bo, Wong, Tien Yin, Luu, Chi D., Agrawal, Rupesh, Ghosh, Arkasubhra, Mortellaro, Alessandra, Rackoczy, Elizabeth, Mohan, Rajiv R., Barathi, Veluchamy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809448/
https://www.ncbi.nlm.nih.gov/pubmed/29434227
http://dx.doi.org/10.1038/s41598-018-21198-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809448/
https://www.ncbi.nlm.nih.gov/pubmed/29434227
http://dx.doi.org/10.1038/s41598-018-21198-z

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