Cargando…

A Prominent Role of Interleukin-18 in Acetaminophen-Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation

Acetaminophen [paracetamol, N-acetyl-p-aminophenol (APAP)]-induced acute liver injury (ALI) not only remains a persistent clinical challenge but likewise stands out as well-characterized paradigmatic model of drug-induced liver damage. APAP intoxication associates with robust hepatic necroinflammati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bachmann, Malte, Pfeilschifter, Josef, Mühl, Heiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809456/ https://www.ncbi.nlm.nih.gov/pubmed/29472923 http://dx.doi.org/10.3389/fimmu.2018.00161

Ejemplares similares

Type I Interferon Supports Inducible Nitric Oxide Synthase in Murine Hepatoma Cells and Hepatocytes and during Experimental Acetaminophen-Induced Liver Damage
por: Bachmann, Malte, et al.
Publicado: (2017)

A murine cellular model of necroinflammation displays RAGE‐dependent cytokine induction that connects to hepatoma cell injury
por: Bachmann, Malte, et al.
Publicado: (2020)

Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity
por: Chichelnitskiy, Evgeny, et al.
Publicado: (2017)

Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury
por: Scheiermann, Patrick, et al.
Publicado: (2015)

Interferon-α curbs production of interleukin-22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi
por: Berner, Anika, et al.
Publicado: (2015)

IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells
por: Wittmann, Miriam, et al.
Publicado: (2012)

Acetaminophen-Induced Liver Injury Exposes Murine IL-22 as Sex-Related Gene Product
por: Stülb, Hendrik, et al.
Publicado: (2021)

STAT3, a Key Parameter of Cytokine-Driven Tissue Protection during Sterile Inflammation – the Case of Experimental Acetaminophen (Paracetamol)-Induced Liver Damage
por: Mühl, Heiko
Publicado: (2016)

Tristetraprolin regulation of interleukin-22 production
por: Härdle, Lorena, et al.
Publicado: (2015)

Erratum: Tristetraprolin regulation of interleukin-22 production
por: Härdle, Lorena, et al.
Publicado: (2015)

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA
por: Sadik, Christian D., et al.
Publicado: (2009)

Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study
por: Kronenberger, Bernd, et al.
Publicado: (2012)

Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice
por: Anzaghe, Martina, et al.
Publicado: (2023)

Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes
por: Berner, Anika, et al.
Publicado: (2016)

Factors associated with significant liver necroinflammation in chronic hepatitis B patients with cirrhosis
por: Chen, Sheng-Sen, et al.
Publicado: (2016)

Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis
por: Nold-Petry, Claudia A., et al.
Publicado: (2010)

3′mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury
por: Gonther, Sina, et al.
Publicado: (2022)

Association between serum sphingolipids and necroinflammation of liver tissue pathology in chronic hepatitis B
por: Ren, Yan, et al.
Publicado: (2022)

IFN-gamma Impairs Release of IL-8 by IL-1beta-stimulated A549 Lung Carcinoma Cells
por: Boost, Kim A, et al.
Publicado: (2008)

Death and fire—the concept of necroinflammation
por: Linkermann, Andreas
Publicado: (2018)

Association between serum S100A9 levels and liver necroinflammation in chronic hepatitis B
por: Wu, Rui, et al.
Publicado: (2018)

Identification of circulating microRNAs as potential biomarkers for hepatic necroinflammation in patients with autoimmune hepatitis
por: Saeki, Chisato, et al.
Publicado: (2022)

Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear Cells Exposed to live Borrelia burgdorferi: The Role of Monocytes and Interleukin-1
por: Bachmann, Malte, et al.
Publicado: (2010)

Cell type-specific roles of NLRP3, inflammasome-dependent and -independent, in host defense, sterile necroinflammation, tissue repair, and fibrosis
por: Honda, Tamisa Seeko Bandeira, et al.
Publicado: (2023)

Neonatal obstructive nephropathy induces necroptosis and necroinflammation
por: Popper, Bastian, et al.
Publicado: (2019)

Discordance between Liver Biopsy and FibroScan® in Assessing Liver Fibrosis in Chronic Hepatitis B: Risk Factors and Influence of Necroinflammation
por: Kim, Seung Up, et al.
Publicado: (2012)

Blockage of Galectin-Receptor Interactions Attenuates Mouse Hepatic Pathology Induced by Toxoplasma gondii Infection
por: He, Jian, et al.
Publicado: (2022)

Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma
por: Bihrer, Verena, et al.
Publicado: (2011)

Serum Golgi Protein 73 as a Potential Biomarker for Hepatic Necroinflammation in Population with Nonalcoholic Steatohepatitis
por: Wang, Leijie, et al.
Publicado: (2020)

Hypothermia Advocates Functional Mitochondria and Alleviates Oxidative Stress to Combat Acetaminophen-Induced Hepatotoxicity
por: Tan, Yeong Lan, et al.
Publicado: (2020)

Plasma Sphingolipids as Potential Indicators of Hepatic Necroinflammation in Patients with Chronic Hepatitis C and Normal Alanine Aminotransferase Level
por: Li, Jun-Feng, et al.
Publicado: (2014)

Interleukin-18 and IL-18 Binding Protein
por: Dinarello, Charles A., et al.
Publicado: (2013)

Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19
por: Tomar, Bhawna, et al.
Publicado: (2020)

Types of necroinflammation, the effect of cell death modalities on sterile inflammation
por: Mázló, Anett, et al.
Publicado: (2022)

Exploring the Diagnostic Potential of Serum Golgi Protein 73 for Hepatic Necroinflammation and Fibrosis in Chronic HCV Infection with Different Stages of Liver Injuries
por: Qian, Xiangjun, et al.
Publicado: (2019)

Circulating MiRNA-122 Levels Are Associated with Hepatic Necroinflammation and Portal Hypertension in HIV/HCV Coinfection
por: Jansen, Christian, et al.
Publicado: (2015)

CD28 Superagonist Shock and Blockage of Motogenic T Cell Cascade
por: Sundqvist, Karl-Gösta
Publicado: (2021)

Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?
por: Mühl, Heiko
Publicado: (2013)

Interleukin-18 and IL-18BP in inflammatory dermatological diseases
por: Wang, Xiaoyun, et al.
Publicado: (2023)

The role of interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer-induced arthritis
por: Fauteux-Daniel, Sebastien, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ahqfemntviaccok4f9johk9l0n