Cargando…

Directed Differentiation of Adult Liver Derived Mesenchymal Like Stem Cells into Functional Hepatocytes

Shortage of functional hepatocytes hampers drug safety testing and therapeutic applications because mature hepatocytes cannot be expanded and maintain functions in vitro. Recent studies have reported that liver progenitor cells can originate from mature hepatocytes in vivo. Derivation of proliferati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Xiaobei, Gupta, Kapish, Ananthanarayanan, Abhishek, Wang, Zenan, Xia, Lei, Li, Aimin, Sakban, Rashidah Binte, Liu, Side, Yu, Hanry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809507/ https://www.ncbi.nlm.nih.gov/pubmed/29434311 http://dx.doi.org/10.1038/s41598-018-20304-5

Ejemplares similares

Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing
por: Tasnim, Farah, et al.
Publicado: (2020)

Mesenchymal Stem Cell-Derived Hepatocytes for Functional Liver Replacement
por: Christ, Bruno, et al.
Publicado: (2012)

Different approaches for transformation of mesenchymal stem cells into hepatocyte-like cells
por: Afshari, Afsoon, et al.
Publicado: (2020)

Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs
por: O’Keeffe, Alec, et al.
Publicado: (2020)

Design and Fabrication of the Vertical-Flow Bioreactor for Compaction Hepatocyte Culture in Drug Testing Application
por: Zhu, Liang, et al.
Publicado: (2021)

Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
por: Choudhury, Yukti, et al.
Publicado: (2017)

Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells
por: Orge, Iasmim Diniz, et al.
Publicado: (2020)

In vitro culture of isolated primary hepatocytes and stem cell-derived hepatocyte-like cells for liver regeneration
por: Hu, Chenxia, et al.
Publicado: (2015)

Hepatocyte and mesenchymal stem cell co-transplantation in rats with acute liver failure
por: Ho, Cheng-Maw, et al.
Publicado: (2020)

Corrigendum: Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
por: Choudhury, Yukti, et al.
Publicado: (2017)

Human Umbilical Cord Mesenchymal Stem Cells and Derived Hepatocyte-Like Cells Exhibit Similar Therapeutic Effects on an Acute Liver Failure Mouse Model
por: Zhou, Ruiping, et al.
Publicado: (2014)

Human Pluripotent Stem Cell-Derived Hepatocyte-Like Cells and Organoids for Liver Disease and Therapy
por: Li, Yang, et al.
Publicado: (2021)

The Effects of Conditioned Medium Derived from Mesenchymal Stem Cells Cocultured with Hepatocytes on Damaged Hepatocytes and Acute Liver Failure in Rats
por: Chen, Li, et al.
Publicado: (2018)

Induction of the differentiation of porcine bone marrow mesenchymal stem cells into premature hepatocyte-like cells in an indirect coculture system with primary hepatocytes
por: Ullah, Imran, et al.
Publicado: (2020)

Adipose tissue-derived mesenchymal stem cells differentiated into hepatocyte-like cells in vivo and in vitro
por: YIN, LIBO, et al.
Publicado: (2015)

Robust protein-based engineering of hepatocyte-like cells from human mesenchymal stem cells
por: Takashina, Tomoki, et al.
Publicado: (2023)

Comparison of the liver function and hepatic specific genes expression in cultured mesenchymal stem cells and hepatocytes
por: Nikoozad, Zahra, et al.
Publicado: (2014)

Hepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells: In Vitro and In Vivo Evaluation
por: El-Kehdy, Hoda, et al.
Publicado: (2016)

Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes
por: He, Juan, et al.
Publicado: (2019)

Induction of hepatocyte‐like cells from human umbilical cord‐derived mesenchymal stem cells by defined microRNAs
por: Zhou, Xia, et al.
Publicado: (2016)

Retinoic Acid as the Stimulating Factor for Differentiation of Wharton's Jelly-Mesenchymal Stem Cells into Hepatocyte-like Cells
por: Mortezaee, Keywan, et al.
Publicado: (2015)

Adipose Tissue-Derived Mesenchymal Stem Cells Extend the Lifespan and Enhance Liver Function in Hepatocyte Organoids
por: Ock, Sun A, et al.
Publicado: (2023)

Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice
por: Xiang, Yan, et al.
Publicado: (2021)

In vitro differentiation of rat mesenchymal stem cells to hepatocyte lineage
por: Sarvandi, Samaneh Solati, et al.
Publicado: (2015)

Hepatocytes direct the formation of a pro-metastatic niche in the liver.
por: Lee, Jae W., et al.
Publicado: (2019)

Differentiation of umbilical cord mesenchymal stem cells into hepatocytes in comparison with bone marrow mesenchymal stem cells
por: Yu, Ya-Bin, et al.
Publicado: (2018)

Wharton’s Jelly Mesenchymal Stem Cell: Various Protocols for Isolation and Differentiation of Hepatocyte-Like Cells; Narrative Review
por: Varaa, Negar, et al.
Publicado: (2019)

Conversion of mesenchymal stem cells into a canine hepatocyte-like cells by Foxa1 and Hnf4a
por: Nitta, Suguru, et al.
Publicado: (2020)

25-Hydroxyvitamin D(3) induces osteogenic differentiation of human mesenchymal stem cells
por: Lou, Yan-Ru, et al.
Publicado: (2017)

Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis
por: Kim, Myung-Deok, et al.
Publicado: (2014)

Direct conversion of porcine primary fibroblasts into hepatocyte-like cells
por: Fráguas-Eggenschwiler, Mariane, et al.
Publicado: (2021)

Phenobarbital Induces Alterations in the Proteome of Hepatocytes and Mesenchymal Cells of Rat Livers
por: Klepeisz, Philip, et al.
Publicado: (2013)

Hepatocyte Growth Factor-Loaded Biomaterials for Mesenchymal Stem Cell Recruitment
por: van de Kamp, Julia, et al.
Publicado: (2013)

Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes
por: Ye, Jun‐Song, et al.
Publicado: (2015)

Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers
por: Chen, Chen, et al.
Publicado: (2018)

Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research
por: Wang, Jingjing, et al.
Publicado: (2019)

Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers
por: Sa-ngiamsuntorn, Khanit, et al.
Publicado: (2011)

Transcriptome Profiling Reveals Distinct Phenotype of Human Bone Marrow Mesenchymal Stem Cell-derived Hepatocyte-like cells
por: Shi, Dongyan, et al.
Publicado: (2020)

Three-dimensional spheroid culture of canine hepatocyte-like cells derived from bone marrow mesenchymal stem cells
por: Nitta, Suguru, et al.
Publicado: (2020)

Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
por: Nakai, Shun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d21h0r2nb0bd4fge4vml1odgtf