Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

Inactivation of constitutive autophagy results in the formation of cytoplasmic inclusions in neurons, but the relationship between impaired autophagy and Lewy bodies (LBs) as well as the in vivo process of formation remains unknown. Synuclein, a component of LBs, is the defining characteristic of Pa...

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Detalles Bibliográficos
Autores principales: Sato, Shigeto, Uchihara, Toshiki, Fukuda, Takahiro, Noda, Sachiko, Kondo, Hiromi, Saiki, Shinji, Komatsu, Masaaki, Uchiyama, Yasuo, Tanaka, Keiji, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809579/
https://www.ncbi.nlm.nih.gov/pubmed/29434298
http://dx.doi.org/10.1038/s41598-018-21325-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809579/
https://www.ncbi.nlm.nih.gov/pubmed/29434298
http://dx.doi.org/10.1038/s41598-018-21325-w

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