Cargando…

Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning

Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest roles in behavioral estimation of location. However, distinguishing the contri...

Descripción completa

Detalles Bibliográficos
Autores principales: Tennant, Sarah A., Fischer, Lukas, Garden, Derek L.F., Gerlei, Klára Zsófia, Martinez-Gonzalez, Cristina, McClure, Christina, Wood, Emma R., Nolan, Matthew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809635/
https://www.ncbi.nlm.nih.gov/pubmed/29386117
http://dx.doi.org/10.1016/j.celrep.2018.01.005
_version_ 1783299601999069184
author Tennant, Sarah A.
Fischer, Lukas
Garden, Derek L.F.
Gerlei, Klára Zsófia
Martinez-Gonzalez, Cristina
McClure, Christina
Wood, Emma R.
Nolan, Matthew F.
author_facet Tennant, Sarah A.
Fischer, Lukas
Garden, Derek L.F.
Gerlei, Klára Zsófia
Martinez-Gonzalez, Cristina
McClure, Christina
Wood, Emma R.
Nolan, Matthew F.
author_sort Tennant, Sarah A.
collection PubMed
description Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest roles in behavioral estimation of location. However, distinguishing the contributions of path integration and cue-based signals to spatial behaviors is challenging, and the roles of identified MEC neurons are unclear. We use virtual reality to dissociate linear path integration from other strategies for behavioral estimation of location. We find that mice learn to path integrate using motor-related self-motion signals, with accuracy that decreases steeply as a function of distance. We show that inactivation of stellate cells in superficial MEC impairs spatial learning in virtual reality and in a real world object location recognition task. Our results quantify contributions of path integration to behavior and corroborate key predictions of models in which stellate cells contribute to location estimation.
format Online
Article
Text
id pubmed-5809635
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cell Press
record_format MEDLINE/PubMed
spelling pubmed-58096352018-02-14 Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning Tennant, Sarah A. Fischer, Lukas Garden, Derek L.F. Gerlei, Klára Zsófia Martinez-Gonzalez, Cristina McClure, Christina Wood, Emma R. Nolan, Matthew F. Cell Rep Article Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest roles in behavioral estimation of location. However, distinguishing the contributions of path integration and cue-based signals to spatial behaviors is challenging, and the roles of identified MEC neurons are unclear. We use virtual reality to dissociate linear path integration from other strategies for behavioral estimation of location. We find that mice learn to path integrate using motor-related self-motion signals, with accuracy that decreases steeply as a function of distance. We show that inactivation of stellate cells in superficial MEC impairs spatial learning in virtual reality and in a real world object location recognition task. Our results quantify contributions of path integration to behavior and corroborate key predictions of models in which stellate cells contribute to location estimation. Cell Press 2018-01-30 /pmc/articles/PMC5809635/ /pubmed/29386117 http://dx.doi.org/10.1016/j.celrep.2018.01.005 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tennant, Sarah A.
Fischer, Lukas
Garden, Derek L.F.
Gerlei, Klára Zsófia
Martinez-Gonzalez, Cristina
McClure, Christina
Wood, Emma R.
Nolan, Matthew F.
Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning
title Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning
title_full Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning
title_fullStr Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning
title_full_unstemmed Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning
title_short Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning
title_sort stellate cells in the medial entorhinal cortex are required for spatial learning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809635/
https://www.ncbi.nlm.nih.gov/pubmed/29386117
http://dx.doi.org/10.1016/j.celrep.2018.01.005
work_keys_str_mv AT tennantsaraha stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning
AT fischerlukas stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning
AT gardendereklf stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning
AT gerleiklarazsofia stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning
AT martinezgonzalezcristina stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning
AT mcclurechristina stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning
AT woodemmar stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning
AT nolanmatthewf stellatecellsinthemedialentorhinalcortexarerequiredforspatiallearning