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Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning
Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest roles in behavioral estimation of location. However, distinguishing the contri...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809635/ https://www.ncbi.nlm.nih.gov/pubmed/29386117 http://dx.doi.org/10.1016/j.celrep.2018.01.005 |
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author | Tennant, Sarah A. Fischer, Lukas Garden, Derek L.F. Gerlei, Klára Zsófia Martinez-Gonzalez, Cristina McClure, Christina Wood, Emma R. Nolan, Matthew F. |
author_facet | Tennant, Sarah A. Fischer, Lukas Garden, Derek L.F. Gerlei, Klára Zsófia Martinez-Gonzalez, Cristina McClure, Christina Wood, Emma R. Nolan, Matthew F. |
author_sort | Tennant, Sarah A. |
collection | PubMed |
description | Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest roles in behavioral estimation of location. However, distinguishing the contributions of path integration and cue-based signals to spatial behaviors is challenging, and the roles of identified MEC neurons are unclear. We use virtual reality to dissociate linear path integration from other strategies for behavioral estimation of location. We find that mice learn to path integrate using motor-related self-motion signals, with accuracy that decreases steeply as a function of distance. We show that inactivation of stellate cells in superficial MEC impairs spatial learning in virtual reality and in a real world object location recognition task. Our results quantify contributions of path integration to behavior and corroborate key predictions of models in which stellate cells contribute to location estimation. |
format | Online Article Text |
id | pubmed-5809635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58096352018-02-14 Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning Tennant, Sarah A. Fischer, Lukas Garden, Derek L.F. Gerlei, Klára Zsófia Martinez-Gonzalez, Cristina McClure, Christina Wood, Emma R. Nolan, Matthew F. Cell Rep Article Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest roles in behavioral estimation of location. However, distinguishing the contributions of path integration and cue-based signals to spatial behaviors is challenging, and the roles of identified MEC neurons are unclear. We use virtual reality to dissociate linear path integration from other strategies for behavioral estimation of location. We find that mice learn to path integrate using motor-related self-motion signals, with accuracy that decreases steeply as a function of distance. We show that inactivation of stellate cells in superficial MEC impairs spatial learning in virtual reality and in a real world object location recognition task. Our results quantify contributions of path integration to behavior and corroborate key predictions of models in which stellate cells contribute to location estimation. Cell Press 2018-01-30 /pmc/articles/PMC5809635/ /pubmed/29386117 http://dx.doi.org/10.1016/j.celrep.2018.01.005 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tennant, Sarah A. Fischer, Lukas Garden, Derek L.F. Gerlei, Klára Zsófia Martinez-Gonzalez, Cristina McClure, Christina Wood, Emma R. Nolan, Matthew F. Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning |
title | Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning |
title_full | Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning |
title_fullStr | Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning |
title_full_unstemmed | Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning |
title_short | Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning |
title_sort | stellate cells in the medial entorhinal cortex are required for spatial learning |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809635/ https://www.ncbi.nlm.nih.gov/pubmed/29386117 http://dx.doi.org/10.1016/j.celrep.2018.01.005 |
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