Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report

BACKGROUND: Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatment modalities or combinations of therapies need to be explored. CASE PRESENTATIO...

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Detalles Bibliográficos
Autores principales: Ahn, Min-joo, Lee, Kanghan, Lee, Kyung Hwa, Kim, Jin Woong, Kim, In-Young, Bae, Woo Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809881/
https://www.ncbi.nlm.nih.gov/pubmed/29433469
http://dx.doi.org/10.1186/s12885-017-3906-0
Descripción
Sumario:BACKGROUND: Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatment modalities or combinations of therapies need to be explored. CASE PRESENTATION: We herein discuss a case of a 38-year-old man initially diagnosed with a gastric cancer brain metastasis. At first, only stereotactic radiosurgery (SRS) was performed, but it was not effective. After the brain and systemic metastases progressed, SRS and anti-PD-1 therapy were administered in combination, and the brain and intra-abdominal metastatic lesions responded satisfactorily. CONCLUSION: The combination of anti-PD-1 therapy and SRS could be effective against gastric cancer with brain metastases.

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