Circular RNAs: a new frontier for cancer diagnosis and therapy

In recent years, circular RNAs (circRNAs) have attracted considerable attention because they play a significant role in many fields of cancer biology. Additionally, it has become increasingly clear that circRNAs have the potential to make contributions to the successful application of individualized...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Miaoci, Xin, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809913/
https://www.ncbi.nlm.nih.gov/pubmed/29433541
http://dx.doi.org/10.1186/s13045-018-0569-5
_version_ 1783299642688012288
author Zhang, Miaoci
Xin, Yan
author_facet Zhang, Miaoci
Xin, Yan
author_sort Zhang, Miaoci
collection PubMed
description In recent years, circular RNAs (circRNAs) have attracted considerable attention because they play a significant role in many fields of cancer biology. Additionally, it has become increasingly clear that circRNAs have the potential to make contributions to the successful application of individualized cancer medicine. This brief review introduces circRNAs by describing their potential as a biomarker and therapeutic target and discussing the possible strategies to target them. This review also presents the challenges that are encountered by circRNAs for their definitive entry into clinical practice. Clearly, our understanding of circRNAs helps to add a new dimension to the molecular structure of cancer and will provide many new opportunities for cancer treatment.
format Online
Article
Text
id pubmed-5809913
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-58099132018-02-16 Circular RNAs: a new frontier for cancer diagnosis and therapy Zhang, Miaoci Xin, Yan J Hematol Oncol Review In recent years, circular RNAs (circRNAs) have attracted considerable attention because they play a significant role in many fields of cancer biology. Additionally, it has become increasingly clear that circRNAs have the potential to make contributions to the successful application of individualized cancer medicine. This brief review introduces circRNAs by describing their potential as a biomarker and therapeutic target and discussing the possible strategies to target them. This review also presents the challenges that are encountered by circRNAs for their definitive entry into clinical practice. Clearly, our understanding of circRNAs helps to add a new dimension to the molecular structure of cancer and will provide many new opportunities for cancer treatment. BioMed Central 2018-02-13 /pmc/articles/PMC5809913/ /pubmed/29433541 http://dx.doi.org/10.1186/s13045-018-0569-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhang, Miaoci
Xin, Yan
Circular RNAs: a new frontier for cancer diagnosis and therapy
title Circular RNAs: a new frontier for cancer diagnosis and therapy
title_full Circular RNAs: a new frontier for cancer diagnosis and therapy
title_fullStr Circular RNAs: a new frontier for cancer diagnosis and therapy
title_full_unstemmed Circular RNAs: a new frontier for cancer diagnosis and therapy
title_short Circular RNAs: a new frontier for cancer diagnosis and therapy
title_sort circular rnas: a new frontier for cancer diagnosis and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809913/
https://www.ncbi.nlm.nih.gov/pubmed/29433541
http://dx.doi.org/10.1186/s13045-018-0569-5
work_keys_str_mv AT zhangmiaoci circularrnasanewfrontierforcancerdiagnosisandtherapy
AT xinyan circularrnasanewfrontierforcancerdiagnosisandtherapy

Ejemplares similares