Cargando…
Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling
Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinson’s disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control di...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810044/ https://www.ncbi.nlm.nih.gov/pubmed/29445770 http://dx.doi.org/10.1523/ENEURO.0366-17.2017 |
_version_ | 1783299674315161600 |
---|---|
author | Mazzoni, A. Rosa, M. Carpaneto, J. Romito, L. M. Priori, A. Micera, S. |
author_facet | Mazzoni, A. Rosa, M. Carpaneto, J. Romito, L. M. Priori, A. Micera, S. |
author_sort | Mazzoni, A. |
collection | PubMed |
description | Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinson’s disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control disorders and addiction is still unclear. Here, we recorded STN local field potentials (LFPs) in PD patients with and without gambling disorder during an economic decision-making task. Reaction times analysis showed that for all patients, the decision whether to risk preceded task onset. We compared then for both groups the STN LFP preceding high- and low-risk economic decisions. We found that risk avoidance in gamblers correlated with larger STN LFP low-frequency (<12-Hz) fluctuations preceding task onset. In particular, the amplitude of low-frequency LFP fluctuations carried significant information about future decisions. Decisions of patients not affected by gambling disorder were instead not correlated with pretask STN LFP. Our results suggest that STN activity preceding task onset affects risk decisions by preemptively inhibiting attraction to high but unlikely rewards in favor of a long-term payoff. |
format | Online Article Text |
id | pubmed-5810044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-58100442018-02-14 Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling Mazzoni, A. Rosa, M. Carpaneto, J. Romito, L. M. Priori, A. Micera, S. eNeuro New Research Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinson’s disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control disorders and addiction is still unclear. Here, we recorded STN local field potentials (LFPs) in PD patients with and without gambling disorder during an economic decision-making task. Reaction times analysis showed that for all patients, the decision whether to risk preceded task onset. We compared then for both groups the STN LFP preceding high- and low-risk economic decisions. We found that risk avoidance in gamblers correlated with larger STN LFP low-frequency (<12-Hz) fluctuations preceding task onset. In particular, the amplitude of low-frequency LFP fluctuations carried significant information about future decisions. Decisions of patients not affected by gambling disorder were instead not correlated with pretask STN LFP. Our results suggest that STN activity preceding task onset affects risk decisions by preemptively inhibiting attraction to high but unlikely rewards in favor of a long-term payoff. Society for Neuroscience 2018-02-06 /pmc/articles/PMC5810044/ /pubmed/29445770 http://dx.doi.org/10.1523/ENEURO.0366-17.2017 Text en Copyright © 2018 Mazzoni et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research Mazzoni, A. Rosa, M. Carpaneto, J. Romito, L. M. Priori, A. Micera, S. Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling |
title | Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling |
title_full | Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling |
title_fullStr | Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling |
title_full_unstemmed | Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling |
title_short | Subthalamic Neural Activity Patterns Anticipate Economic Risk Decisions in Gambling |
title_sort | subthalamic neural activity patterns anticipate economic risk decisions in gambling |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810044/ https://www.ncbi.nlm.nih.gov/pubmed/29445770 http://dx.doi.org/10.1523/ENEURO.0366-17.2017 |
work_keys_str_mv | AT mazzonia subthalamicneuralactivitypatternsanticipateeconomicriskdecisionsingambling AT rosam subthalamicneuralactivitypatternsanticipateeconomicriskdecisionsingambling AT carpanetoj subthalamicneuralactivitypatternsanticipateeconomicriskdecisionsingambling AT romitolm subthalamicneuralactivitypatternsanticipateeconomicriskdecisionsingambling AT prioria subthalamicneuralactivitypatternsanticipateeconomicriskdecisionsingambling AT miceras subthalamicneuralactivitypatternsanticipateeconomicriskdecisionsingambling |