Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

BACKGROUND: ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular...

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Detalles Bibliográficos
Autores principales: Turzo, Maurizio, Vaith, Julian, Lasitschka, Felix, Weigand, Markus A., Busch, Cornelius J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810061/
https://www.ncbi.nlm.nih.gov/pubmed/29433570
http://dx.doi.org/10.1186/s12931-018-0735-x

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