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Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania
OBJECTIVE: The gap between patients diagnosed with multi-drug resistant tuberculosis (MDR-TB) and enrolment in treatment is one of the major challenges in tuberculosis control programmes. A 4-year (2013–2016) retrospective review of patients’ clinical data and subsequent in-depth interviews with hea...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810180/ https://www.ncbi.nlm.nih.gov/pubmed/29426372 http://dx.doi.org/10.1186/s13104-018-3235-7 |
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author | Mnyambwa, Nicholaus Peter Lekule, Issack Ngadaya, Esther S. Kimaro, Godfather Petrucka, Pammla Kim, Dong-Jin Lymo, Johnson Kazwala, Rudovick Mosha, Fausta Mfinanga, Sayoki G. |
author_facet | Mnyambwa, Nicholaus Peter Lekule, Issack Ngadaya, Esther S. Kimaro, Godfather Petrucka, Pammla Kim, Dong-Jin Lymo, Johnson Kazwala, Rudovick Mosha, Fausta Mfinanga, Sayoki G. |
author_sort | Mnyambwa, Nicholaus Peter |
collection | PubMed |
description | OBJECTIVE: The gap between patients diagnosed with multi-drug resistant tuberculosis (MDR-TB) and enrolment in treatment is one of the major challenges in tuberculosis control programmes. A 4-year (2013–2016) retrospective review of patients’ clinical data and subsequent in-depth interviews with health providers were conducted to assess the effectiveness of the GeneXpert GxAlert platform for MDR-TB diagnosis and its impact on linkage of patients to care in Tanzania. RESULTS: A total of 782 new rifampicin resistant cases were notified, but only 242 (32.3%) were placed in an MDR-TB regimens. The remaining 540 (67.07%) patients were not on treatment, of which 103 patients had complete records on the GxAlert database. Of the 103 patients: 39 were judged as untraceable; 27 died before treatment; 12 were treated with first-line anti-TBs; 9 repeat tests did not show rifampicin resistance; 15 were not on treatment due to communication breakdown, and 1 patient was transferred outside the country. In-depth interviews with health providers suggested that the pre-treatment loss for the MDR-TB patients was primarily attributed to health system and patients themselves. We recommend strengthening the health system by developing and implementing well-defined interventions to ensure all diagnosed MDR-TB patients are accurately reported and timely linked to treatment. |
format | Online Article Text |
id | pubmed-5810180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58101802018-02-16 Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania Mnyambwa, Nicholaus Peter Lekule, Issack Ngadaya, Esther S. Kimaro, Godfather Petrucka, Pammla Kim, Dong-Jin Lymo, Johnson Kazwala, Rudovick Mosha, Fausta Mfinanga, Sayoki G. BMC Res Notes Research Note OBJECTIVE: The gap between patients diagnosed with multi-drug resistant tuberculosis (MDR-TB) and enrolment in treatment is one of the major challenges in tuberculosis control programmes. A 4-year (2013–2016) retrospective review of patients’ clinical data and subsequent in-depth interviews with health providers were conducted to assess the effectiveness of the GeneXpert GxAlert platform for MDR-TB diagnosis and its impact on linkage of patients to care in Tanzania. RESULTS: A total of 782 new rifampicin resistant cases were notified, but only 242 (32.3%) were placed in an MDR-TB regimens. The remaining 540 (67.07%) patients were not on treatment, of which 103 patients had complete records on the GxAlert database. Of the 103 patients: 39 were judged as untraceable; 27 died before treatment; 12 were treated with first-line anti-TBs; 9 repeat tests did not show rifampicin resistance; 15 were not on treatment due to communication breakdown, and 1 patient was transferred outside the country. In-depth interviews with health providers suggested that the pre-treatment loss for the MDR-TB patients was primarily attributed to health system and patients themselves. We recommend strengthening the health system by developing and implementing well-defined interventions to ensure all diagnosed MDR-TB patients are accurately reported and timely linked to treatment. BioMed Central 2018-02-09 /pmc/articles/PMC5810180/ /pubmed/29426372 http://dx.doi.org/10.1186/s13104-018-3235-7 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Mnyambwa, Nicholaus Peter Lekule, Issack Ngadaya, Esther S. Kimaro, Godfather Petrucka, Pammla Kim, Dong-Jin Lymo, Johnson Kazwala, Rudovick Mosha, Fausta Mfinanga, Sayoki G. Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania |
title | Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania |
title_full | Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania |
title_fullStr | Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania |
title_full_unstemmed | Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania |
title_short | Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania |
title_sort | assessment of genexpert gxalert platform for multi-drug resistant tuberculosis diagnosis and patients’ linkage to care in tanzania |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810180/ https://www.ncbi.nlm.nih.gov/pubmed/29426372 http://dx.doi.org/10.1186/s13104-018-3235-7 |
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