HMGB1 bound to cisplatin–DNA adducts undergoes extensive acetylation and phosphorylation in vivo

Cisplatin, one of the most effective anticancer drugs, is a DNA-damaging agent that induces cell death primarily by apoptosis. For many years, HMGB1 has been known to be a recognition protein for cisplatin–DNA lesions. Here, an application of a biomolecular probe based on a peptide–oligonucleotide c...

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Detalles Bibliográficos
Autores principales: He, Yafeng, Ding, Yin, Wang, Dan, Zhang, Wanjun, Chen, Weizhong, Liu, Xichun, Qin, Weijie, Qian, Xiaohong, Chen, Hao, Guo, Zijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810237/
https://www.ncbi.nlm.nih.gov/pubmed/29449921
http://dx.doi.org/10.1039/c4sc03650f

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