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The Origins of Specificity in the Microcin-Processing Protease TldD/E

TldD and TldE proteins are involved in the biosynthesis of microcin B17 (MccB17), an Escherichia coli thiazole/oxazole-modified peptide toxin targeting DNA gyrase. Using a combination of biochemical and crystallographic methods we show that E. coli TldD and TldE interact to form a heterodimeric meta...

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Detalles Bibliográficos
Autores principales:	Ghilarov, Dmitry, Serebryakova, Marina, Stevenson, Clare E.M., Hearnshaw, Stephen J., Volkov, Dmitry S., Maxwell, Anthony, Lawson, David M., Severinov, Konstantin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810440/ https://www.ncbi.nlm.nih.gov/pubmed/28943336 http://dx.doi.org/10.1016/j.str.2017.08.006

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