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Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study

OBJECTIVE: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. PATIENTS AND METHODS...

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Autores principales: Yang, Weina, Gu, Lina, Yang, Chang, Liu, Tianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810516/
https://www.ncbi.nlm.nih.gov/pubmed/29445289
http://dx.doi.org/10.2147/OTT.S154188
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author Yang, Weina
Gu, Lina
Yang, Chang
Liu, Tianbo
author_facet Yang, Weina
Gu, Lina
Yang, Chang
Liu, Tianbo
author_sort Yang, Weina
collection PubMed
description OBJECTIVE: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. PATIENTS AND METHODS: Immunohistochemical method was performed using tissues from 130 patients with CSCC. The associations between NLK expression and the clinicopathological factors and prognosis of CSCCs were evaluated. Statistical analyses were performed using the chi-square test, the multivariate Cox proportional hazard model, and the Kaplan–Meier method. RESULTS: Immunohistochemical staining analysis showed that NLK was localized predominately in the nucleus of the tumor cells, and increased NLK expression was detected in 71 (54.6%) of 130 patients. NLK overexpression significantly correlated with higher histological grade (P=0.001), vascular/lymphatic invasion (P=0.010), lymph node metastasis (P=0.012), and recurrence (P=0.022). Patients with elevated NLK expression had poorer overall survival (OS) and disease-free survival (DFS) (P=0.006 and P=0.004, respectively) compared with patients with decreased NLK expression. Multivariate Cox analysis demonstrated that NLK overexpression was an independent factor for OS and DFS (P=0.034 and P=0.025, respectively). CONCLUSION: NLK may be a valuable biomarker for predicting the prognosis of CSCC patients and may serve as a potential target for cancer therapy.
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spelling pubmed-58105162018-02-14 Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study Yang, Weina Gu, Lina Yang, Chang Liu, Tianbo Onco Targets Ther Original Research OBJECTIVE: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. PATIENTS AND METHODS: Immunohistochemical method was performed using tissues from 130 patients with CSCC. The associations between NLK expression and the clinicopathological factors and prognosis of CSCCs were evaluated. Statistical analyses were performed using the chi-square test, the multivariate Cox proportional hazard model, and the Kaplan–Meier method. RESULTS: Immunohistochemical staining analysis showed that NLK was localized predominately in the nucleus of the tumor cells, and increased NLK expression was detected in 71 (54.6%) of 130 patients. NLK overexpression significantly correlated with higher histological grade (P=0.001), vascular/lymphatic invasion (P=0.010), lymph node metastasis (P=0.012), and recurrence (P=0.022). Patients with elevated NLK expression had poorer overall survival (OS) and disease-free survival (DFS) (P=0.006 and P=0.004, respectively) compared with patients with decreased NLK expression. Multivariate Cox analysis demonstrated that NLK overexpression was an independent factor for OS and DFS (P=0.034 and P=0.025, respectively). CONCLUSION: NLK may be a valuable biomarker for predicting the prognosis of CSCC patients and may serve as a potential target for cancer therapy. Dove Medical Press 2018-02-08 /pmc/articles/PMC5810516/ /pubmed/29445289 http://dx.doi.org/10.2147/OTT.S154188 Text en © 2018 Yang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Yang, Weina
Gu, Lina
Yang, Chang
Liu, Tianbo
Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
title Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
title_full Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
title_fullStr Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
title_full_unstemmed Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
title_short Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
title_sort expression of nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810516/
https://www.ncbi.nlm.nih.gov/pubmed/29445289
http://dx.doi.org/10.2147/OTT.S154188
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