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Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
OBJECTIVE: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. PATIENTS AND METHODS...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810516/ https://www.ncbi.nlm.nih.gov/pubmed/29445289 http://dx.doi.org/10.2147/OTT.S154188 |
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author | Yang, Weina Gu, Lina Yang, Chang Liu, Tianbo |
author_facet | Yang, Weina Gu, Lina Yang, Chang Liu, Tianbo |
author_sort | Yang, Weina |
collection | PubMed |
description | OBJECTIVE: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. PATIENTS AND METHODS: Immunohistochemical method was performed using tissues from 130 patients with CSCC. The associations between NLK expression and the clinicopathological factors and prognosis of CSCCs were evaluated. Statistical analyses were performed using the chi-square test, the multivariate Cox proportional hazard model, and the Kaplan–Meier method. RESULTS: Immunohistochemical staining analysis showed that NLK was localized predominately in the nucleus of the tumor cells, and increased NLK expression was detected in 71 (54.6%) of 130 patients. NLK overexpression significantly correlated with higher histological grade (P=0.001), vascular/lymphatic invasion (P=0.010), lymph node metastasis (P=0.012), and recurrence (P=0.022). Patients with elevated NLK expression had poorer overall survival (OS) and disease-free survival (DFS) (P=0.006 and P=0.004, respectively) compared with patients with decreased NLK expression. Multivariate Cox analysis demonstrated that NLK overexpression was an independent factor for OS and DFS (P=0.034 and P=0.025, respectively). CONCLUSION: NLK may be a valuable biomarker for predicting the prognosis of CSCC patients and may serve as a potential target for cancer therapy. |
format | Online Article Text |
id | pubmed-5810516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58105162018-02-14 Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study Yang, Weina Gu, Lina Yang, Chang Liu, Tianbo Onco Targets Ther Original Research OBJECTIVE: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. PATIENTS AND METHODS: Immunohistochemical method was performed using tissues from 130 patients with CSCC. The associations between NLK expression and the clinicopathological factors and prognosis of CSCCs were evaluated. Statistical analyses were performed using the chi-square test, the multivariate Cox proportional hazard model, and the Kaplan–Meier method. RESULTS: Immunohistochemical staining analysis showed that NLK was localized predominately in the nucleus of the tumor cells, and increased NLK expression was detected in 71 (54.6%) of 130 patients. NLK overexpression significantly correlated with higher histological grade (P=0.001), vascular/lymphatic invasion (P=0.010), lymph node metastasis (P=0.012), and recurrence (P=0.022). Patients with elevated NLK expression had poorer overall survival (OS) and disease-free survival (DFS) (P=0.006 and P=0.004, respectively) compared with patients with decreased NLK expression. Multivariate Cox analysis demonstrated that NLK overexpression was an independent factor for OS and DFS (P=0.034 and P=0.025, respectively). CONCLUSION: NLK may be a valuable biomarker for predicting the prognosis of CSCC patients and may serve as a potential target for cancer therapy. Dove Medical Press 2018-02-08 /pmc/articles/PMC5810516/ /pubmed/29445289 http://dx.doi.org/10.2147/OTT.S154188 Text en © 2018 Yang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yang, Weina Gu, Lina Yang, Chang Liu, Tianbo Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study |
title | Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study |
title_full | Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study |
title_fullStr | Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study |
title_full_unstemmed | Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study |
title_short | Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study |
title_sort | expression of nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810516/ https://www.ncbi.nlm.nih.gov/pubmed/29445289 http://dx.doi.org/10.2147/OTT.S154188 |
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