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Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation

Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxid...

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Detalles Bibliográficos
Autores principales: Fan, Junsheng, Fong, Tszhei, Chen, Xinjie, Chen, Chuyun, Luo, Peng, Xie, Haiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810533/
https://www.ncbi.nlm.nih.gov/pubmed/29445286
http://dx.doi.org/10.2147/NDT.S157099
Descripción
Sumario:Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases.