Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation

Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxid...

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Autores principales: Fan, Junsheng, Fong, Tszhei, Chen, Xinjie, Chen, Chuyun, Luo, Peng, Xie, Haiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810533/
https://www.ncbi.nlm.nih.gov/pubmed/29445286
http://dx.doi.org/10.2147/NDT.S157099
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author Fan, Junsheng
Fong, Tszhei
Chen, Xinjie
Chen, Chuyun
Luo, Peng
Xie, Haiting
author_facet Fan, Junsheng
Fong, Tszhei
Chen, Xinjie
Chen, Chuyun
Luo, Peng
Xie, Haiting
author_sort Fan, Junsheng
collection PubMed
description Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases.
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spelling pubmed-58105332018-02-14 Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation Fan, Junsheng Fong, Tszhei Chen, Xinjie Chen, Chuyun Luo, Peng Xie, Haiting Neuropsychiatr Dis Treat Review Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases. Dove Medical Press 2018-02-09 /pmc/articles/PMC5810533/ /pubmed/29445286 http://dx.doi.org/10.2147/NDT.S157099 Text en © 2018 Fan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Fan, Junsheng
Fong, Tszhei
Chen, Xinjie
Chen, Chuyun
Luo, Peng
Xie, Haiting
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
title Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
title_full Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
title_fullStr Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
title_full_unstemmed Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
title_short Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
title_sort glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810533/
https://www.ncbi.nlm.nih.gov/pubmed/29445286
http://dx.doi.org/10.2147/NDT.S157099
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