Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

The mechanisms by which mitochondrial metabolism supports cancer anabolism are still unclear. Here, we unexpectedly find that genetic and pharmacological inactivation of Pyruvate Dehydrogenase A1 (PDHA1), a subunit of pyruvate dehydrogenase complex (PDC) inhibits prostate cancer development in diffe...

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Detalles Bibliográficos
Autores principales: Chen, Jingjing, Guccini, Ilaria, Di Mitri, Diletta, Brina, Daniela, Revandkar, Ajinkya, Sarti, Manuela, Pasquini, Emiliano, Alajati, Abdullah, Pinton, Sandra, Losa, Marco, Civenni, Gianluca, Catapano, Carlo V., Sgrignani, Jacopo, Cavalli, Andrea, D'Antuono, Rocco, Asara, John M., Morandi, Andrea, Chiarugi, Paola, Crotti, Sara, Agostini, Marco, Montopoli, Monica, Masgras, Ionica, Rasola, Andrea, Garcia-Escudero, Ramon, Delaleu, Nicolas, Rinaldi, Andrea, Bertoni, Francesco, de Bono, Johann, Carracedo, Arkaitz, Alimonti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810912/
https://www.ncbi.nlm.nih.gov/pubmed/29335542
http://dx.doi.org/10.1038/s41588-017-0026-3

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